Ibrutinib Therapy and Mycobacterium chelonae Skin and Soft Tissue Infection

被引：14
作者：
Dousa, Khalid M. [1 ]
Babiker, Ahmed [2 ]
Van Aartsen, Daniel [1 ]
Shah, Neel [2 ]
Bonomo, Robert A. [3 ,4 ,5 ,6 ,7 ,8 ,9 ]
Johnson, John L. [1 ]
Skalweit, Marion J. [3 ]
机构：
[1] Univ Hosp Cleveland, Med Ctr, Div Infect Dis & HIV Med, Foley Bldg,Room 416,11100 Euclid Ave, Cleveland, OH 44106 USA
[2] Univ Pittsburgh, Med Ctr, Div Infect Dis, Pittsburgh, OH USA
[3] Vet Affairs Med Ctr, Louis Stokes Cleveland Dept, Infect Dis Sect, Cleveland, OH USA
[4] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA
[5] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA
[6] Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA
[7] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA
[8] Case Western Reserve Univ, Sch Med, Dept Prote & Bioinformat, Cleveland, OH 44106 USA
[9] CWRU Cleveland VAMC Ctr Antimicrobial Resistance, Cleveland, OH USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2018年 / 5卷 / 07期
关键词：
chronic lymphocytic leukemia; ibrutinib; Mycobacterium chelonae; nontuberculous mycobacteria; skin and soft tissue infection; KINASE INHIBITORS;
D O I：
10.1093/ofid/ofy168
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase approved for the treatment of B-cell malignancies. There is growing concern about the risk of opportunistic infections following ibrutinib therapy. Herein, we describe the first case of Mycobacterium chelonae skin and soft tissue infection in a patient receiving ibrutinib and recount the challenges in treating this infection.
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页数：3
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