Ibrutinib Therapy and Mycobacterium chelonae Skin and Soft Tissue Infection

被引：13

作者：

Dousa, Khalid M. ^{[1
]}

Babiker, Ahmed ^{[2
]}

Van Aartsen, Daniel ^{[1
]}

Shah, Neel ^{[2
]}

Bonomo, Robert A. ^{[3
,4
,5
,6
,7
,8
,9
]}

Johnson, John L. ^{[1
]}

Skalweit, Marion J. ^{[3
]}

机构：

[1] Univ Hosp Cleveland, Med Ctr, Div Infect Dis & HIV Med, Foley Bldg,Room 416,11100 Euclid Ave, Cleveland, OH 44106 USA

[2] Univ Pittsburgh, Med Ctr, Div Infect Dis, Pittsburgh, OH USA

[3] Vet Affairs Med Ctr, Louis Stokes Cleveland Dept, Infect Dis Sect, Cleveland, OH USA

[4] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA

[6] Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA

[7] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

[8] Case Western Reserve Univ, Sch Med, Dept Prote & Bioinformat, Cleveland, OH 44106 USA

[9] CWRU Cleveland VAMC Ctr Antimicrobial Resistance, Cleveland, OH USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2018年 / 5卷 / 07期

关键词：

chronic lymphocytic leukemia; ibrutinib; Mycobacterium chelonae; nontuberculous mycobacteria; skin and soft tissue infection; KINASE INHIBITORS;

D O I：

10.1093/ofid/ofy168

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase approved for the treatment of B-cell malignancies. There is growing concern about the risk of opportunistic infections following ibrutinib therapy. Herein, we describe the first case of Mycobacterium chelonae skin and soft tissue infection in a patient receiving ibrutinib and recount the challenges in treating this infection.

引用

页数：3

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