Cancer stem cells: At the headwaters of tumor development

被引：121
作者：
Ward, Ryan J.
Dirks, Peter B.
机构：
[1] Hosp Sick Children, Program Dev Biol, Toronto, ON M5G 1X8, Canada
[2] Hosp Sick Children, Div Neurosurg, Toronto, ON M5G 1X8, Canada
[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
来源：
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2007年 / 2卷
关键词：
D O I：
10.1146/annurev.pathol.2.010506.091847
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
According to the cancer stem cell hypothesis, only a subpopulation of cells within a cancer has the capacity to sustain tumor growth. This subpopulation of cells is made up of cancer stem cells, which are defined simply as the population of cells within a tumour that can self-renew, differentiate, and regenerate a phenocopy of the cancer when injected in vivo. Cancer stem cells have now been prospectively isolated from human cancers of the blood, breast, and brain, and putative cancer stem cells have been identified from human skin, bone, and prostate tumors and from multiple established mammalian cancer cell lines. Furthermore, researchers are actively seeking cancer stem cells hi every human cancer type. We present the current scientific evidence supporting the cancer stem cell hypothesis and discuss the experimental and therapeutic implications of the discovery of human cancer stem cells.
引用
收藏
页码：175 / 189
页数：15
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