Thyroid Dysplasia in Wistar Hannover GALAS Rats

被引：10

作者：

Weber, Klaus ^{[1
]}

Ernst, Rainer ^{[2
]}

Fankhauser, Heinz ^{[3
]}

Hardisty, Jerry F. ^{[4
]}

Heider, Wolfram ^{[2
]}

Stevens, Karla ^{[5
]}

机构：

[1] Harlan Labs Ltd, CH-4452 Itingen, Switzerland

[2] Schering AG, D-13342 Berlin, Germany

[3] RCC Ltd, CH-4452 Itingen, Switzerland

[4] EPL Inc, Res Triangle Pk, NC 27709 USA

[5] Harlan Labs Inc, Indianapolis, IN 46250 USA

来源：

JOURNAL OF TOXICOLOGIC PATHOLOGY | 2009年 / 22卷 / 04期

基金：

美国国家卫生研究院;

关键词：

thyroid gland dysplasia; pituitary dwarfism; GALAS rats;

D O I：

10.1293/tox.22.247

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Thyroid dysplasia was recognized in WistarHan GALAS rats and confirmed as a heritable congenital disorder. The gene or genes involved were not identified, but homozygous animals with thyroid dysplasia also exhibited stunted growth, had reduced pituitary gland growth hormone (GH) and were hypothyroid. Heterozygous animals exhibited thyroid dysplasia with normal thyroid hormonal homeostasis and no difference in the incidence of preneoplastic or neoplastic lesions in oncogenicity studies. (J Toxicol Pathol 2009; 22: 247-254)

引用

页码：247 / 254

页数：8

共 6 条

[1] EFFECTS OF NEONATAL HYPOTHYROIDISM AND HYPER-THYROIDISM ON PITUITARY GROWTH-HORMONE CONTENT IN THE RAT [J].