Synthesis and Evaluation of Novel 2-Substituted-quinazolin-4(3H)-ones as Potent Analgesic and Anti-inflammatory Agents

被引：15

作者：

Rather, Bilal Ahmad ^{[2
]}

Raj, Tilak ^{[2
]}

Reddy, Aravind ^{[1
]}

Ishar, Mohan Paul S. ^{[2
]}

Sivakumar, Samitha ^{[1
]}

Paneerselvam, Perumal ^{[1
]}

机构：

[1] CL Baid Metha Coll Pharm, Dept Pharmaceut Chem, Madras 600097, Tamil Nadu, India

[2] Guru Nanak Dev Univ, Dept Pharmaceut Sci, Bioorgan & Photochem Lab, Amritsar, Punjab, India

来源：

ARCHIV DER PHARMAZIE | 2010年 / 343卷 / 02期

关键词：

Analgesic; Anti-inflammatory activity; Quinazolines; Quinazolinones; PHARMACOLOGICAL EVALUATION; QUINAZOLIN-4-ONES; QUINAZOLONES;

D O I：

10.1002/ardp.200900231

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of 2-substituted-quinazolin-4(3H)-ones were synthesized by reacting 3,5-disubstituted-anthranilic acid with acetic anhydride/benzoyl chloride, which were further reacted with different primary airlines to obtain 2,6,8-substituted-quinazolin-4(3H)-ones 6a-f, 7, 8. All the synthesized compounds were characterized and screened for analgesic and anti-inflammatory activities. Compounds 6,8-dibromo-2-phenyl-3-(4'-carboxyk phenyl)quinazolin-4(3H)-one 7 and 6,8-dibromo-2-phenyl-3-(2'-phenylethanoic acid)quinazolin-4(3H)-one 8 displayed good analgesic and anti-inflammatory activity in comparison to the reference standards acetyl salicylic acid and indomethacin, respectively.

引用

页码：108 / 113

页数：6

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