C-type lectin family XIV members and angiogenesis

被引：14
作者：
Borah, Supriya [1 ,2 ]
Vasudevan, Dileep [1 ]
Swain, Rajeeb K. [1 ]
机构：
[1] Inst Life Sci, Nalco Sq,Nalco Nagar Rd, Bhubaneswar 751023, Odisha, India
[2] Manipal Acad Higher Educ, Dept Biotechnol, Manipal 576104, Karnataka, India
来源：
ONCOLOGY LETTERS | 2019年 / 18卷 / 04期
关键词：
C-type lectin family XIV; angiogenesis; CLEC14A; thrombomodulin; CD93; endosialin; SQUAMOUS-CELL CARCINOMA; CIRCULATING THROMBOMODULIN LEVELS; INCREASED PLASMA THROMBOMODULIN; VASCULAR ENDOTHELIAL-CELLS; FOCAL ADHESION KINASE; TUMOR ANGIOGENESIS; SPROUTING ANGIOGENESIS; PROMOTES ANGIOGENESIS; ELEVATED EXPRESSION; ENDOSIALIN TEM1;
D O I：
10.3892/ol.2019.10760
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The growth and metastasis of tumors is dependent on angiogenesis. C-type lectins are carbohydrate-binding proteins with a diverse range of functions. The C-type lectin family XIV members are transmembrane glycoproteins, and all four members of this family have been reported to regulate angiogenesis, although the detailed mechanism of action has yet to be completely elucidated. They interact with extracellular matrix proteins and mediate cell-cell adhesion by their lectin-like domain. The aim of the present study was to summarize the available information on the function and mechanism of C-type lectin family XIV in angiogenesis and discuss their potential as targets for cancer therapy.
引用
收藏
页码：3954 / 3962
页数：9
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