Highly emissive hybrid mesoporous organometallo-silica nanoparticles for bioimaging

被引：10

作者：

Ezquerro, Cintia ^{[1
]}

Lopez, Iciar P. ^{[2
]}

Serrano, Elena ^{[3
]}

Alfaro-Arnedo, Elvira ^{[2
]}

Lalinde, Elena ^{[1
]}

Larrayoz, Ignacio M. ^{[4
,5
]}

Pichel, Jose G. ^{[2
,6
]}

Garcia-Martinez, Javier ^{[3
]}

Berenguer, Jesus R. ^{[1
]}

机构：

[1] Univ La Rioja, Dept Quim, Ctr Invest Sintesis Quim CISQ, Madre de Dios 53, E-26006 Logrono, La Rioja, Spain

[2] Fdn Rioja Salud, Ctr Invest Biomed La Rioja CIBIR, Unidad Canc Pulmon & Enfermedades Resp, Logrono 26006, La Rioja, Spain

[3] Univ Alicante, Dept Quim Inorgan, Lab Nanotecnol Mol, Carretera San Vicente S-N, E-03690 Alicante, Spain

[4] Fdn Rioja Salud, Ctr Invest Biomed La Rioja CIBIR, Unidad Biomarcadores & Senalizac Mol, Logrono 26006, La Rioja, Spain

[5] Univ La Rioja, Unidad Predept Enfermeria, GRUPAC, Duquesa de la Victoria 88, E-26006 Logrono, La Rioja, Spain

[6] Spanish Biomed Res Networking Ctr Resp Dis CIBERE, ISCIII, E-28029 Madrid, Spain

来源：

MATERIALS ADVANCES | 2022年 / 3卷 / 08期

关键词：

ELECTROGENERATED CHEMILUMINESCENCE; SURFACE FUNCTIONALIZATION; BIOMEDICAL APPLICATIONS; IRIDIUM(III) COMPLEXES; IR(III) COMPLEXES; PROBES; CONVERSION; DELIVERY; THERAPY; DESIGN;

D O I：

10.1039/d1ma01243f

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Production of mesoporous silica nanoparticles (MSNs) with uniform textural characteristics and imaging properties on a large scale is still a challenge. Thus, the design of simple and scalable methods to obtain reproducible functionalized MSNs has become even more relevant. Herein, we describe an in situ strategy for the synthesis and surface functionalization of highly luminescent mesoporous organometallo-silica nanoparticles. Using the [Ir(dfppy)(2)(dasipy)]PF6 chromophore and TEOS as sol-gel precursors and different capping agents, such as DMDES or APTES, three different emissive MSNs were prepared (NPOH_IS, NPMe_IS and NPNH2_IS), each containing hydroxyl, methyl and amine groups on their surfaces, respectively. All three were tested on human tumor A549 (lung carcinoma) and HeLa (cervix carcinoma) cell lines, showing intense and stable yellow phosphorescence, biocompatibility and efficient internalization. Moreover, NPMe_IS nanoparticles showed excellent colloidal stability, both in water and biological media, and a BET area of 1120 m(2) g(-1), making them not only luminescent biomarkers, but potentially also controlled delivery vectors.

引用

页码：3582 / 3592

页数：11

共 95 条

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