Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase

被引：309

作者：

Kim, Sangwon F.

Huang, Alex S.

Snowman, Adele M.

Teuscher, Cory

Snyder, Solomon H.

机构：

[1] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[4] Univ Vermont, Coll Med, Dept Med, Burlington, VT 05405 USA

[5] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 09期

关键词：

atypical antipsychotic drugs; obesity; hypothalamus;

D O I：

10.1073/pnas.0611417104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We report that orexigenic AAPDs potently and selectively activate hypothalamic AMP-kinase, an action abolished in mice with deletion of histamine H1 receptors. These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake.

引用

页码：3456 / 3459

页数：4

共 40 条

[1] Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents [J].