Association between vitamin D3 and glutathione levels in COVID-19 individual

Background: COVID-19 is an infectious disease associated with a high rate of infection and death, especially for the older males when they have low levels of glutathione (GSH) and vitamin D. The GSH status is positively associated with the bioavailability of vitamin D. The GSH deficiency is correlated by increased oxidative stress and inflammatory markers which implicate the increase in the severity of the disease. Objective: To verify the vitamin D-GSH levels interaction among healthy and COVID- 19 patients. Method: Control healthy group (166) individuals and (171) COVID-19 patients were involved in this study. Oxidative stress and antioxidant parameters, vitamin D, and inflammatory markers were estimated in both Results: The COVID-19 patients showed significantly higher levels of malondialdehyde (MDA), protein and significantly low levels of GSH and vitamin D compared to the healthy control group, the aged and male COVID-19 group display significantly higher levels of MDA, PC, and significantly low levels for GSH Conclusion: The COVID-19 patient correlated with higher oxidative stress, inflammatory marker, and low level of antioxidant GSH and vitamin D which occur with advancing age, especially within the male.