Discovery of a natural thiamine adenine nucleotide

被引：73

作者：

Bettendorff, Lucien

Wirtzfeld, Barbara

Makarchikov, Alexander F.

Mazzucchelli, Gabriel

Frederich, Michel

Gigliobianco, Tiziana

Gangolf, Marjorie

De Pauw, Edwin

Angenot, Luc

Wins, Pierre

机构：

[1] Univ Liege, Ctr Cellular & Mol Neurobiol, B-4000 Liege, Belgium

[2] Univ Liege, Dept Phys Chem, B-4000 Liege, Belgium

[3] Univ Liege, Drug Res Ctr, Lab Pharmacognosy, B-4000 Liege, Belgium

来源：

NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 04期

关键词：

D O I：

10.1038/nchembio867

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.

引用

页码：211 / 212

页数：2

共 8 条

[1] Structural basis for transcription regulation by alarmone ppGpp
Artsimovitch, I
Patlan, V
Sekine, SI
Vassylyeva, MN
Hosaka, T
Ochi, K
Yokoyama, S
Vassylyev, DG
[J]. CELL, 2004, 117 (03) : 299 - 310
[2] DETERMINATION OF THIAMIN AND ITS PHOSPHATE-ESTERS IN CULTURED NEURONS AND ASTROCYTES USING AN ION-PAIR REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD
BETTENDORFF, L
PEETERS, M
JOUAN, C
WINS, P
SCHOFFENIELS, E
[J]. ANALYTICAL BIOCHEMISTRY, 1991, 198 (01) : 52 - 59
[3] A general method for the chemical synthesis of γ-32P-labeled or unlabeled nucleoside 5′-triphosphates and thiamine triphosphate
Bettendorff, L
Nghiêm, HO
Wins, P
Lakaye, B
[J]. ANALYTICAL BIOCHEMISTRY, 2003, 322 (02) : 190 - 197
[4] 2 COMPOUNDS IMPLICATED IN FUNCTION OF RC GENE OF ESCHERICHIA COLI
CHASHEL, M
GALLANT, J
[J]. NATURE, 1969, 221 (5183) : 838 - &
[5] Thiamin biosynthesis in eukaryotes:: Characterization of the enzyme-bound product of thiazole synthase from Saccharomyces cerevisiae and its implications in thiazole biosynthesis
Chatterjee, Abhishek
Jurgenson, Christopher T.
Schroeder, Frank C.
Ealick, Steven E.
Begley, Tadhg P.
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (22) : 7158 - 7159
[6] Thiamine triphosphate, a new signal required for optimal growth of Escherichia coli during amino acid starvation
Lakaye, B
Wirtzfeld, B
Wins, P
Grisar, T
Bettendorff, L
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (17) : 17142 - 17147
[7] Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals
Makarchikov, AF
Lakaye, B
Gulyai, IE
Czerniecki, J
Coumans, B
Wins, P
Grisar, T
Bettendorff, L
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2003, 60 (07) : 1477 - 1488
[8] The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography
Wille, Georg
Meyer, Danilo
Steinmetz, Andrea
Hinze, Erik
Golbik, Ralph
Tittmann, Kai
[J]. NATURE CHEMICAL BIOLOGY, 2006, 2 (06) : 324 - 328

← 1 →