Helicobacter pylori CagL Hypervariable Motif: A Global Analysis of Geographical Diversity and Association With Gastric Cancer

被引：23
作者：
Gorrell, Rebecca J. [1 ,2 ,3 ,4 ]
Zwickel, Nicolas [1 ,2 ,3 ]
Reynolds, John [6 ,7 ,8 ]
Bulach, Dieter [5 ,9 ]
Kwok, Terry [1 ,2 ,3 ,4 ]
机构：
[1] Monash Univ, Infect & Immun Program, Clayton, Vic 3800, Australia
[2] Monash Univ, Monash Biomed Discovery Inst, Canc Program, Clayton, Vic 3800, Australia
[3] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia
[4] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia
[5] Monash Univ, Victorian Bioinformat Consortium, Clayton, Vic 3800, Australia
[6] Monash Univ, Fac Med Nursing & Hlth Sci, Biostat Consulting Platform, Melbourne, Vic 3004, Australia
[7] Alfred Ctr, Melbourne, Vic, Australia
[8] The Alfred, Clin Haematol, Prahran, Vic, Australia
[9] Victorian Life Sci Computat Initiat, Life Sci Computat Ctr, Carlton, Vic, Australia
来源：
JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 12期
关键词：
Helicobacter pylori; CagL; gastric cancer; gastritis; peptic ulcer disease; integrin; geographical diversity; host/pathogen co-evolution; host/pathogen interaction; sequence polymorphism; IV SECRETION; ADHESION; EXPRESSION; INTEGRIN; PROTEIN;
D O I：
10.1093/infdis/jiw060
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Previous studies suggest overrepresentation of particular polymorphisms within the Helicobacter pylori CagL hypervariable motif (CagLHM) in gastric cancer-associated isolates. However, these disease correlations were geographically variable and ambiguous. We compared the disease correlation of several hundred geographically diverse CagL sequences and identified 33 CagLHM sequence combinations with disparate geographical distribution, revealing substantial worldwide CagLHM diversity, particularly within Asian countries. Notably, polymorphisms E59 and I60 were significantly overrepresented, whereas D58 and E62 were underrepresented, in gastric cancer-associated H. pylori isolates worldwide. Thus, CagLHM regional diversity may contribute to the varied prevalence of H. pylori-related gastric cancer observed in diverse populations.
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收藏
页码：1927 / 1931
页数：5
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