Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis

被引：13

作者：

Catalan, Ana ^{[1
,2
]}

Tognin, Stefania ^{[1
,3
]}

Kempton, Matthew J. ^{[1
,4
]}

Stahl, Daniel ^{[5
]}

Salazar de Pablo, Gonzalo ^{[6
,7
]}

Nelson, Barnaby ^{[8
,9
]}

Pantelis, Christos ^{[10
,11
]}

Riecher-Rossler, Anita ^{[12
]}

Bressan, Rodrigo ^{[13
]}

Barrantes-Vidal, Neus ^{[14
]}

Krebs, Marie-Odile ^{[15
,16
]}

Nordentoft, Merete ^{[17
,18
]}

Ruhrmann, Stephan ^{[19
,20
,21
]}

Sachs, Gabriele ^{[22
]}

Rutten, Bart P. F. ^{[23
]}

van Os, Jim ^{[1
,23
,24
]}

de Haan, Lieuwe ^{[25
]}

van der Gaag, Mark ^{[26
,27
,28
]}

Valmaggia, Lucia R. ^{[4
,29
]}

McGuire, Philip ^{[1
,3
,4
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[2] Univ Basque Country, Dept Mental Hlth, Biocruces Bizkaia Hlth Res Inst, Basurto Univ Hosp,Fac Med & Odontol,UPV EHU, Campus Leioa,Plaza Cruces 12, Baracaldo, Bizkaia, Spain

[3] South London & Maudsley NHS Fdn Trust, Outreach & Support South London OASIS Serv, Likondon, England

[4] Biomed Res Ctr BRC, Natl Inst Hlth Res NIHR, London, England

[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Biostat & Hlth Informat, London, England

[6] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London, England

[7] Univ Complutense, Hosp Gen Univ Gregorio Maranon,CIBERSAM, Inst Psychiat & Mental Hlth,Dept Child & Adolesce, Inst Invest Sanitaria Gregorio Maranon IiSGM,Sch, Madrid, Spain

[8] Orygen, Parkville, Vic, Australia

[9] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia

[10] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Carlton, Vic, Australia

[11] Melbourne Hlth, Carlton, Vic, Australia

[12] Univ Basel, Med Fac, Basel, Switzerland

[13] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, LiNC Lab Integrat Neurosci, Escola Paulista Med, Sao Paulo, Brazil

[14] Univ Autonoma Barcelona, Spanish Mental Hlth Res Network CIBERSAM, Dept Psicol Clin & Salut, Fundacio Sanitaria St Pere Claver, Madrid, Spain

[15] Univ Paris, Inst Psychiat CNRS GDR 3557, Lab Physiopathol Malad Psychiat, IPNP UMR S1266,INSERM, Paris, France

[16] Pole Hosp Univ PEPIT CJAAD, Fac Med Paris Descartes, GHU Paris St Anne, Paris, France

[17] Univ Copenhagen, Mental Hlth Serv Capital Reg Copenhagen, Mental Hlth Ctr Glostrup, CINS,Mental Hlth Ctr Copenhagen, Copenhagen, Denmark

[18] Univ Copenhagen, Mental Hlth Serv Capital Reg Copenhagen, Mental Hlth Ctr Glostrup, CINS,Ctr Clin Intervent & Neuropsychiat Schizophr, Copenhagen, Denmark

[19] Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne, Germany

[20] Univ Cologne, Dept Psychiat & Psychotherapy, Fac Med, Cologne, Germany

[21] Univ Cologne, Univ Hosp, Cologne, Germany

[22] Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria

[23] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Mental Hlth & Neurosci MHeNS, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[24] Univ Utrecht, UMC Utrecht Brain Ctr, Dept Psychiat, Med Ctr, Utrecht, Netherlands

[25] Amsterdam UMC, Early Psychosis Dept, Amsterdam, Netherlands

[26] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Dept Clin Psychol, Amsterdam, Netherlands

[27] Amsterdam Publ Mental Hlth Res Inst, Amsterdam, Netherlands

[28] Parnassia Psychiat Inst, Dept Psychosis Res, The Hague, Netherlands

[29] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London, England

来源：

PSYCHOLOGICAL MEDICINE | 2022年 / 52卷 / 08期

基金：

英国医学研究理事会;

关键词：

Functioning; psychosis; transition to psychosis; ultra high-risk; REASONING BIASES; DELUSIONAL CONVICTION; SCHIZOPHRENIA; INDIVIDUALS; SCALE; RELIABILITY; MECHANISMS; SYMPTOMS; VALIDITY;

D O I：

10.1017/S0033291720003396

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. Methods In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. Results There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; chi 2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ. Conclusions In CHR participants, JTC at baseline was associated with adverse functioning at the follow-up. Interventions designed to improve JTC could be beneficial in the CHR population.

引用

页码：1569 / 1577

页数：9

共 54 条

[1]

American Psychiatric Association, 2013, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425596

[2]

ANDREASEN NC, 1982, ARCH GEN PSYCHIAT, V39, P784

[3]

[Anonymous], 1995, STRUCTURED CLIN INTE

[4]

[Anonymous], 2017, Stata: Release 17. Statistical Software, DOI [10.2307/2234838, DOI 10.2307/2234838]