Hyperlipidaemia and cardioprotection: Animal models for translational studies

被引：47

作者：

Andreadou, Ioanna ^{[1
]}

Schulz, Rainer ^{[2
]}

Badimon, Lina ^{[3
,4
,5
]}

Adameova, Adriana ^{[6
,7
]}

Kleinbongard, Petra ^{[8
]}

Lecour, Sandrine ^{[9
]}

Nikolaou, Panagiota-Efstathia ^{[1
]}

Falcao-Pires, Ines ^{[10
]}

Vilahur, Gemma ^{[3
,4
]}

Woudberg, Nicholas ^{[9
]}

Heusch, Gerd ^{[8
]}

Ferdinandy, Peter ^{[11
,12
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Fac Pharm, Lab Pharmacol, Athens 15771, Greece

[2] Justus Liebig Univ Giessen, Inst Physiol, Giessen, Germany

[3] Res Inst Hosp Santa Creu & St Pau, IIB St Pau, Cardiovasc Program ICCC, Barcelona, Spain

[4] Inst Salud Carlos III, CIBERCV, Madrid, Spain

[5] Autonomous Univ Barcelona, Cardiovasc Res Chair, Barcelona, Spain

[6] Comenius Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bratislava, Slovakia

[7] Slovak Acad Sci, Ctr Expt Med, Inst Heart Res, Bratislava, Slovakia

[8] Univ Klinikum Essen, Westdeutsch Herz & Gefasszentrum, Inst Pathophysiol, Essen, Germany

[9] Univ Cape Town, Fac Hlth Sci, Hatter Inst Cardiovasc Res Africa, Dept Med, Cape Town, South Africa

[10] Univ Porto, Fac Med, Dept Cirurgia & Fisiol, Unidade Invest Cardiovasc, Porto, Portugal

[11] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, Nagyvarad Ter 4, Budapest, Hungary

[12] Pharmahungary Grp, Szeged, Hungary

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2020年 / 177卷 / 23期

关键词：

HIGH-DENSITY-LIPOPROTEIN; ISCHEMIA-REPERFUSION INJURY; CORONARY-ARTERY-DISEASE; ESTER TRANSFER PROTEIN; INFARCT SIZE; METABOLIC SYNDROME; KNOCKOUT MICE; ISCHEMIA/REPERFUSION INJURY; SPHINGOSINE; 1-PHOSPHATE; ATHEROSCLEROTIC LESIONS;

D O I：

10.1111/bph.14931

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hyperlipidaemia is a well-established risk factor for cardiovascular diseases and therefore, many animal model have been developed to mimic the human abnormal elevation of blood lipid levels. In parallel, extensive research for the alleviation of ischaemia/reperfusion injury has revealed that hyperlipidaemia is a major co-morbidity that attenuates the cardioprotective effect of conditioning strategies (preconditioning, postconditioning and remote conditioning) and that of pharmacological interventions by interfering with cardioprotective signalling pathways. In the present review article, we summarize the existing data on animal models of hypercholesterolaemia (total, low density and HDL abnormalities) and hypertriglyceridaemia used in ischaemia/reperfusion injury and protection from it. We also provide recommendations on preclinical animal models to be used for translations of the cardioprotective strategies into clinical practice.

引用

页码：5287 / 5311

页数：25

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