Intrinsic functional connectivity of the periaqueductal gray, a resting fMRI study

被引：155

作者：

Kong, Jian ^{[1
,2
]}

Tu, Pei-chi ^{[1
]}

Zyloney, Carolyn ^{[1
]}

Su, Tung-ping ^{[3
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA 02129 USA

[2] MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi, Charlestown, MA USA

[3] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan

来源：

BEHAVIOURAL BRAIN RESEARCH | 2010年 / 211卷 / 02期

关键词：

Periaqueductal gray; PAG; Pain; fMRI; Resting state; Functional connectivity; DIABETIC NEUROPATHIC PAIN; MEDIAL PREFRONTAL CORTEX; ELECTRICAL-STIMULATION; PLACEBO ANALGESIA; NEURAL MECHANISMS; MAJOR DEPRESSION; HUMAN BRAIN; HPA AXIS; NETWORK; HUMANS;

D O I：

10.1016/j.bbr.2010.03.042

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The periaqueductal gray (PAG) is known to play a crucial role in pain modulation and has shown a strong interaction with anterior cingulate cortex in previous functional imaging studies. We investigated the intrinsic functional connectivity of PAG using resting fMRI data from 100 subjects. The results showed that PAG is functionally connected to ACC (rostral and pregenual ACC) and also rostral ventromedial medulla (RVM), forming a core ACC-PAG-RVM network for pain modulation even no pain stimulus is applied. The comparison between genders showed that for the contrast of female minus male, significant difference was observed at mid-cingulate cortex; for the contrast of male minus female, significant differences were observed at left medial orbital prefrontal cortex, and uncus; right insula/operculum and prefrontal cortex. We believe eluciation of this intrinsic PAG network duing the resting state will enhance our physiological and pathological understandings of the development and maintenance of chronic pain states. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：215 / 219

页数：5

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