Epigenetic alterations in chronic disease focusing on Behcet's disease: Review

被引：49

作者：

Alipour, Shahriar ^{[1
,2
]}

Nouri, Mohammad ^{[3
]}

Sakhinia, Ebrahim ^{[3
]}

Samadi, Nasser ^{[3
]}

Roshanravan, Neda ^{[4
]}

Ghavami, Abed ^{[4
]}

Khabbazi, Alireza ^{[2
]}

机构：

[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Mol Med, Tabriz, Iran

[2] Tabriz Univ Med Sci, Connect Tissue Dis Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Dept Biochem, Fac Med, Tabriz, Iran

[4] Tabriz Univ Med Sci, Sch Nutr, Nutr Res Ctr, Tabriz, Iran

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 91卷

关键词：

Epigenetic; Autoimmune diseases; Behcet's disease; Methylation; microRNAs; DNA METHYLATION; MULTIPLE-SCLEROSIS; RHEUMATOID-ARTHRITIS; HISTONE MODIFICATIONS; T-CELLS; EXPRESSION; PROMOTER; CHROMATIN; MICRORNA; PATHOGENESIS;

D O I：

10.1016/j.biopha.2017.04.106

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: 'Epigenetics' is specified as the inheritable changes in gene expression with no alterations in DNA sequences. Epigenetics is a rapidly overspreading scientific field, and the study of epigenetic regulation in chronic disease is emerging. This study aims to evaluate epigenetic changes including DNA methylation, histone modification, and non-coding RNAs (ncRNAs) in inflammatory disease, with focus on Behcet's disease. In this review, first we describe the history and classification of epigenetic changes, and then the role of epigenetic alterations in chronic diseases is explained. Methods: Systematic search of MEDLINE, Embase, and Cochrane Library was conducted for all comparative studies since 2000 to 2015 with the limitations of the English language. Results: For a notable period of time, researchers have mainly focused on the epigenetic pathways that are involved in the modulation of inflammatory and anti-inflammatory genes. Recent studies have proposed a central role for chronic inflammation in the pathogenesis of chronic disease, including Behcet's disease. Conclusion: Studies have been reported on the epigenetic of BD showed the role of alterations in the methylation level of IRS elements; histone modifications such as H3K4me27 and H3K4me3; up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease. (C) 2017 Published by Elsevier Masson SAS.

引用

页码：526 / 533

页数：8

共 112 条

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