Complexity of bone marrow hematopoietic stem cell niche

被引：107

作者：

Asada, Noboru ^{[1
,2
]}

Takeishi, Shoichiro ^{[1
,2
]}

Frenette, Paul S. ^{[1
,2
,3
]}

机构：

[1] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, 1301 Morris Pk Ave, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2017年 / 106卷 / 01期

关键词：

Hematopoietic stem cell; Niche; Perivascular niche; Niche factor; N-CADHERIN; ENDOTHELIAL-CELLS; PROGENITOR CELLS; SELF-RENEWAL; IN-VITRO; SUPPORT; MEGAKARYOCYTES; MAINTENANCE; QUIESCENCE; LOCALIZATION;

D O I：

10.1007/s12185-017-2262-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematopoietic stem cells (HSCs) that produce a variety of hematopoietic lineage cells throughout the life reside in specialized microenvironment called "niche" in the bone marrow (BM) where they are tightly regulated. With the recent advances in experimental technologies enabling the selective deletion of molecules, various types of cells in the BM have been proposed to contribute to HSC niche activity. Among these are stromal cells closely associated with the vasculature. In this review, we provide an overview of recent advances in HSC niche research, and focus on the studies describing the functional roles of perivascular cells for HSC maintenance and mobilization. Not only for physiologic state, we also discuss the recent evidences suggesting the importance of microenvironment for emergence of malignant hematopoietic diseases.

引用

页码：45 / 54

页数：10

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