Although intestinal microbiota plays an important role in the metabolism of procyanidins, the microbial metabolic pathway of A-type procyanidins remains elusive. In this study, A-type dimer procyanidin A1 [EC-(28-O7,48-8)-C] and trimer PPD [EC-(48-6)-EC-(28-O-7,48-8)-C] were incubated with rat faecal microbiota in vitro, and their metabolomic profiles were analyzed by UPLC-QTOF/MS. Multivariate statistical analysis identified 24 and 30 discriminant metabolites for A1 and PPD, respectively. The C-ring opened catabolites of procyanidin A1 and PPD and the typical phenolic acid metabolites were identified, including phenylacetic acid, (4 '-hydroxyphenyl)acetic acid, 3-phenylpropanoic acid, 3-(4 '-hydroxyphenyl)propanoic acid, 3-(3 ',4 '-dihydroxyphenyl) propanoic acid, and 5-(3 ',4 '-dihydroxyphenyl)-gamma-valerolactone. Notably, procyanidin A1 and (epi)catechin were identified from the metabolites of PPD; however, no (epi)catechin was found in the metabolites of procyanidin A1, indicating that the faecal microbiota can destroy B-type linkage (C4-C6 interflavan bond) but not A-type linkage (C4-C8 and additional C2-O-C7 interflavan bond) in the metabolism of A-type procyanidins.
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Univ Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, ScotlandUniv Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland
Borges, Gina
van der Hooft, Justin J. J.
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Univ Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland
Univ Glasgow, Coll Med Vet & Life Sci, Wolfson Wohl Canc Res Ctr, Glasgow Poly, Glasgow, Lanark, ScotlandUniv Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland
van der Hooft, Justin J. J.
Crozier, Alan
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Univ Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, ScotlandUniv Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland
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Univ Liverpool, Liverpool L69 3GE, Merseyside, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Toh, Cheng Hock
Williamson, Paula
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Univ Liverpool, Liverpool L69 3GE, Merseyside, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Williamson, Paula
Daly, Ann K.
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Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Daly, Ann K.
Kamali, Farhad
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Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Kamali, Farhad
Deloukas, Panos
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Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
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Catholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, BelgiumCatholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, Belgium
De Taeye, Cedric
Caullet, Gilles
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Catholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, BelgiumCatholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, Belgium
Caullet, Gilles
Evina, Victor Jos Eyamo
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Catholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, BelgiumCatholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, Belgium
Evina, Victor Jos Eyamo
Collin, Sonia
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Catholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, BelgiumCatholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, Belgium
机构:
Univ Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, ScotlandUniv Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland
Borges, Gina
van der Hooft, Justin J. J.
论文数: 0引用数: 0
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机构:
Univ Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland
Univ Glasgow, Coll Med Vet & Life Sci, Wolfson Wohl Canc Res Ctr, Glasgow Poly, Glasgow, Lanark, ScotlandUniv Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland
van der Hooft, Justin J. J.
Crozier, Alan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, ScotlandUniv Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland
机构:
Univ Liverpool, Liverpool L69 3GE, Merseyside, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Toh, Cheng Hock
Williamson, Paula
论文数: 0引用数: 0
h-index: 0
机构:
Univ Liverpool, Liverpool L69 3GE, Merseyside, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Williamson, Paula
Daly, Ann K.
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Daly, Ann K.
Kamali, Farhad
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h-index: 0
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Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Kamali, Farhad
Deloukas, Panos
论文数: 0引用数: 0
h-index: 0
机构:
Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, EnglandWellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
机构:
Catholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, BelgiumCatholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, Belgium
De Taeye, Cedric
Caullet, Gilles
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h-index: 0
机构:
Catholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, BelgiumCatholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, Belgium
Caullet, Gilles
Evina, Victor Jos Eyamo
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h-index: 0
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Catholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, BelgiumCatholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, Belgium
Evina, Victor Jos Eyamo
Collin, Sonia
论文数: 0引用数: 0
h-index: 0
机构:
Catholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, BelgiumCatholic Univ Louvain, Fac Bioingenieurs, Unite Brasserie & Ind Alimentaires, Earth & Life Inst,ELIM, 2 Bte L07-05-07, B-1348 Louvain La Neuve, Belgium