Current trends in oxysterol research

被引：45

作者：

Griffiths, William J. ^{[1
]}

Abdel-Khalik, Jonas ^{[1
]}

Hearn, Thomas ^{[1
]}

Yutuc, Eylan ^{[1
]}

Morgan, Alwena H. ^{[1
]}

Wang, Yuqin ^{[1
]}

机构：

[1] Swansea Univ, Coll Med, Grove Bldg,Singleton Pk, Swansea SA2 8PP, W Glam, Wales

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2016年 / 44卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

cholestenoic acid; cholesterol; hydroxycholesterol; liver X receptor (LXR); RAR-related orphan receptor gamma t (ROR gamma); sterol regulatory-element binding protein (SREBP); CHOLESTEROL HOMEOSTASIS; CELL-MIGRATION; 27-HYDROXYCHOLESTEROL; ACID; METABOLISM; STEROL; LIGANDS; BRAIN; MOUSE; 24S-HYDROXYCHOLESTEROL;

D O I：

10.1042/BST20150255

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the immune system, particularly with respect to bacterial and viral infection and to T(h)17-cell development, and the role of oxysterols in breast cancer. We also discuss the value of oxysterol analysis in the diagnosis of disease.

引用

页码：652 / 658

页数：7

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