Human Papillomavirus-Related Head and Neck Cancer

被引：29

作者：

Wagner, Steffen ^{[1
]}

Sharma, Shachi Jenny ^{[1
]}

Wuerdemann, Nora ^{[1
]}

Knuth, Jennifer ^{[1
]}

Reder, Henrike ^{[1
]}

Wittekindt, Claus ^{[1
]}

Klussmann, Jens Peter ^{[1
]}

机构：

[1] Univ Giessen, Dept Otorhinolaryngol Head & Neck Surg, Aulweg 128, D-35392 Giessen, Germany

来源：

ONCOLOGY RESEARCH AND TREATMENT | 2017年 / 40卷 / 06期

关键词：

Head and neck; Oropharynx; Human papillomavirus; HPV; Viral transformation; Epidemiology; Diagnostics; SQUAMOUS-CELL CARCINOMAS; SIGNATURE PREDICTS SURVIVAL; OROPHARYNGEAL CARCINOMA; E7; ONCOPROTEIN; NO EVIDENCE; VIRAL LOAD; HPV-DNA; EXPRESSION; METHYLATION; P16(INK4A);

D O I：

10.1159/000477252

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human papillomavirus(HPV)-related head and neck cancer is recognized as a distinct tumor entity with rising incidence reported for several countries. These tumors arise from squamous cells, typically in the oropharynx. In contrast to cancer associated with other risk factors, HPV-related cancer is driven by viral oncoprotein activity and has individual profiles regarding protein expression, and genetic and epigenetic alterations. Molecular characteristics are p16IN4A overexpression, absence of p53 inactivating mutations, and PI3K/AKT and Wnt pathway modulation. Patients with HPV-related head and neck cancer have improved survival compared to those with HPV-negative tumors, and p16(INK4A) staining has been introduced into tumor staging recently. However, no specific or toxicity-reduced treatment modalities have been established for this entity so far. Although the still incomplete and partially inconsistent data in this field needs further study, particular features of HPV-related cancers such as specific microRNA expression, immunology, or gene methylation patterns certainly have the potential to be implemented in future diagnostic and therapeutic concepts. (C) 2017 S. Karger GmbH, Freiburg

引用

页码：334 / 340

页数：7

共 60 条

[1] Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 [J].

Agrawal, Nishant ;

Frederick, Mitchell J. ;

Pickering, Curtis R. ;

Bettegowda, Chetan ;

Chang, Kyle ;

Li, Ryan J. ;

Fakhry, Carole ;

Xie, Tong-Xin ;

Zhang, Jiexin ;

Wang, Jing ;

Zhang, Nianxiang ;

El-Naggar, Adel K. ;

Jasser, Samar A. ;

Weinstein, John N. ;

Trevino, Lisa ;

Drummond, Jennifer A. ;

Muzny, Donna M. ;

Wu, Yuanqing ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Westra, William H. ;

Koch, Wayne M. ;

Califano, Joseph A. ;

Gibbs, Richard A. ;

Sidransky, David ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

Papadopoulos, Nickolas ;

Wheeler, David A. ;

Kinzler, Kenneth W. ;

Myers, Jeffrey N. .

SCIENCE, 2011, 333 (6046) :1154-1157

[2]

Amin MB, 2017, AJCC CANC STAGING MA, V8th, DOI [10.1007/978-3-319-40618-3, DOI 10.1007/978-3-319-40618-3]

[3] Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study [J].

Anantharaman, Devasena ;

Gheit, Tarik ;

Waterboer, Tim ;

Abedi-Ardekani, Behnoush ;

Carreira, Christine ;

McKay-Chopin, Sandrine ;

Gaborieau, Valerie ;

Marron, Manuela ;

Lagiou, Pagona ;

Ahrens, Wolfgang ;

Holcatova, Ivana ;

Merletti, Franco ;

Kjaerheim, Kristina ;

Talamini, Renato ;

Simonato, Lorenzo ;

Castellsague, Xavier ;

Macfarlane, Tatiana V. ;

Biggs, Anne-Marie ;

Thakker, Nalin ;

Znaor, Ariana ;

Thomson, Peter ;

Canova, Cristina ;

Conway, David I. ;

Healy, Claire M. ;

Tommasino, Massimo ;

Pawlita, Michael ;

Brennan, Paul .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2013, 105 (08) :536-545

[4]

Andl T, 1998, CANCER RES, V58, P5

[5]

[Anonymous], 2015, WHO report on the global tobacco epidemic

[6] HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients [J].

Castellsague, Xavier ;

Alemany, Laia ;

Quer, Miquel ;

Halec, Gordana ;

Quiros, Beatriz ;

Tous, Sara ;

Clavero, Omar ;

Alos, Llucia ;

Biegner, Thorsten ;

Szafarowski, Tomasz ;

Alejo, Maria ;

Holzinger, Dana ;

Cadena, Enrique ;

Claros, Edith ;

Hall, Gillian ;

Laco, Jan ;

Poljak, Mario ;

Benevolo, Maria ;

Kasamatsu, Elena ;

Mehanna, Hisham ;

Ndiaye, Cathy ;

Guimera, Nuria ;

Lloveras, Belen ;

Leon, Xavier ;

Ruiz-Cabezas, Juan C. ;

Alvarado-Cabrero, Isabel ;

Kang, Chang-Suk ;

Oh, Jin-Kyoung ;

Garcia-Rojo, Marcial ;

Iljazovic, Ermina ;

Ajayi, Oluseyi F. ;

Duarte, Flora ;

Nessa, Ashrafun ;

Tinoco, Leopoldo ;

Duran-Padilla, Marco A. ;

Pirog, Edyta C. ;

Viarheichyk, Halina ;

Morales, Hesler ;

Costes, Valerie ;

Felix, Ana ;

Germar, Maria Julieta V. ;

Mena, Marisa ;

Ruacan, Arzu ;

Jain, Asha ;

Mehrotra, Ravi ;

Goodman, Marc T. ;

Lombardi, Luis Estuardo ;

Ferrera, Annabelle ;

Malami, Sani ;

Albanesi, Estela I. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2016, 108 (06)

[7] Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions [J].

Chaiwongkot, Arkom ;

Vinokurova, Svetlana ;

Pientong, Chamsai ;

Ekalaksananan, Tipaya ;

Kongyingyoes, Bunkerd ;

Kleebkaow, Pilaiwan ;

Chumworathayi, Bandit ;

Patarapadungkit, Natcha ;

Reuschenbach, Miriam ;

Doeberitz, Magnus von Knebel .

INTERNATIONAL JOURNAL OF CANCER, 2013, 132 (09) :2087-2094

[8] Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States [J].

Chaturvedi, Anil K. ;

Engels, Eric A. ;

Pfeiffer, Ruth M. ;

Hernandez, Brenda Y. ;

Xiao, Weihong ;

Kim, Esther ;

Jiang, Bo ;

Goodman, Marc T. ;

Sibug-Saber, Maria ;

Cozen, Wendy ;

Liu, Lihua ;

Lynch, Charles F. ;

Wentzensen, Nicolas ;

Jordan, Richard C. ;

Altekruse, Sean ;

Anderson, William F. ;

Rosenberg, Philip S. ;

Gillison, Maura L. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (32) :4294-4301

[9] Prevalence of human papillomavirus in tonsil brushings and gargles in cancer-free patients: The SPLIT study [J].

Combes, Jean-Damien ;

Dalstein, Veronique ;

Gheit, Tarik ;

Clifford, Gary M. ;

Tommasino, Massimo ;

Clavel, Christine ;

St Guily, Jean Lacau ;

Franceschi, Silvia .

ORAL ONCOLOGY, 2017, 66 :52-57

[10] Role of Cdk1 in DNA damage-induced G1 checkpoint abrogation by the human papillomavirus E7 oncogene [J].

Fan, Xueli ;

Chen, Jason J. .

CELL CYCLE, 2014, 13 (20) :3249-3259

← 1 2 3 4 5 6 →