Motoring along with the bacterial RecA protein

被引：196
作者：
Cox, Michael M. [1 ]
机构：
[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm2099
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The recombinases of the RecA family are often viewed only as DNA-pairing proteins-they bind to one DNA segment, align it with homologous sequences in another DNA segment, promote an exchange of DNA strands and then dissociate. To a first approximation, this description seems to fit the eukaryotic (Rad51 and Dmc1) and archaeal (RadA) RecA homologues. However, the bacterial RecA protein does much more, coupling ATP hydrolysis with DNA-strand exchange in a manner that greatly expands its repertoire of activities. This article explores the protein activities and experimental results that have identified RecA as a motor protein.
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收藏
页码：127 / 138
页数：12
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