Motoring along with the bacterial RecA protein

被引：197

作者：

Cox, Michael M. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2099

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recombinases of the RecA family are often viewed only as DNA-pairing proteins-they bind to one DNA segment, align it with homologous sequences in another DNA segment, promote an exchange of DNA strands and then dissociate. To a first approximation, this description seems to fit the eukaryotic (Rad51 and Dmc1) and archaeal (RadA) RecA homologues. However, the bacterial RecA protein does much more, coupling ATP hydrolysis with DNA-strand exchange in a manner that greatly expands its repertoire of activities. This article explores the protein activities and experimental results that have identified RecA as a motor protein.

引用

页码：127 / 138

页数：12

共 109 条

[1] STRUCTURE AT 2.8-ANGSTROM RESOLUTION OF F1-ATPASE FROM BOVINE HEART-MITOCHONDRIA [J].

ABRAHAMS, JP ;

LESLIE, AGW ;

LUTTER, R ;

WALKER, JE .

NATURE, 1994, 370 (6491) :621-628

[2] STRUCTURAL MODEL OF THE ATP-BINDING DOMAIN OF THE F-1-BETA SUBUNIT BASED ON ANALOGY TO THE RECA PROTEIN [J].

AMANO, T ;

YOSHIDA, M ;

MATSUO, Y ;

NISHIKAWA, K .

FEBS LETTERS, 1994, 351 (01) :1-5

[3] Quantitative analysis of the kinetics of end-dependent disassembly of RecA filaments from ssDNA [J].

Arenson, TA ;

Tsodikov, OV ;

Cox, MM .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 288 (03) :391-401

[4] The human Rad51 protein: polarity of strand transfer and stimulation by hRP-A [J].

Baumann, P ;

West, SC .

EMBO JOURNAL, 1997, 16 (17) :5198-5206

[5] Evidence for the coupling of ATP hydrolysis to the final (extension) phase of RecA protein-mediated DNA strand exchange [J].

Bedale, WA ;

Cox, MM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (10) :5725-5732

[6]

BENEDICT RC, 1988, J BIOL CHEM, V263, P15513

[7] Modeling of nucleotide binding domains of ABC transporter proteins based on a F1-ATPase/recA topology:: Structural model of the nucleotide binding domains of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) [J].

Bianchet, MA ;

Ko, YH ;

Amzel, LM ;

Pedersen, PL .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1997, 29 (05) :503-524

[8] ESCHERICHIA-COLI RECA PROTEIN POSSESSES A STRAND SEPARATING ACTIVITY ON SHORT DUPLEX DNAS [J].

BIANCHI, M ;

RIBOLI, B ;

MAGNI, G .

EMBO JOURNAL, 1985, 4 (11) :3025-3030

[9] INSERTIONS, DELETIONS AND MISMATCHES IN HETERODUPLEX DNA MADE BY RECA-PROTEIN [J].

BIANCHI, ME ;

RADDING, CM .

CELL, 1983, 35 (02) :511-520

[10]

BIANCO PR, 1998, FRONT BIOSCI, V3, P560

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