Non-pharmacological interventions for cognitive impairment in women with breast cancer post-chemotherapy: A systematic review

被引：15

作者：

Floyd, Ruairi ^{[1
]}

Dyer, Adam H. ^{[2
,3
]}

Kennelly, Sean P. ^{[2
,3
]}

机构：

[1] Univ Limerick, Grad Entry Med Sch, Limerick, Ireland

[2] Tollaght Univ Hosp, Dept Age Related Healthcare, Dublin, Ireland

[3] Trinity Coll Dublin, Dept Med Gerontol, Sch Med, Dublin, Ireland

来源：

JOURNAL OF GERIATRIC ONCOLOGY | 2021年 / 12卷 / 02期

关键词：

ADJUVANT CHEMOTHERAPY; DOUBLE-BLIND; SURVIVORS; DYSFUNCTION; THERAPY; FATIGUE; TRIAL; METAANALYSIS; MODAFINIL; CARCINOMA;

D O I：

10.1016/j.jgo.2020.05.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Cognitive impairment is a well-reported side-effect of chemotherapy in persons with breast cancer. Whilst non-pharmacological interventions have proven efficacious in the management of cognitive impairment in high-risk groups, their efficacy in cognitive impairment post-chemotherapy in patients with breast cancer remains unclear. Methods: Medline, CINAHL, PsycINFO, Web of Science and Cochrane were searched for randomized controlled trials of non-pharmacological interventions for cognitive impairment post-chemotherapy in women with breast cancer. Results: Of 429 results, 83 full-texts were reviewed with ten meeting inclusion criteria. Interventions included cognitive training, exercise and complementary therapies. The non-pharmacological interventions assessed displayed variable benefits in subjective and/or objective cognitive assessments, with no strong evidence for beneficial effects across included studies. No studies assessed the efficacy of multi-domain interventions. Conclusions: There is mixed evidence supporting non-pharmacological interventions for cognitive impairment post-chemotherapy in women with breast cancer. Moving forward, multidomain trials combining non-pharmacological interventions are imperative in this high risk cohort. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：173 / 181

页数：9

共 67 条

[21] Does tumor necrosis factor-alpha (TNF-α) play a role in post-chemotherapy cerebral dysfunction? [J].

Ganz, Patricia A. ;

Bower, J. E. ;

Kwan, L. ;

Castellon, S. A. ;

Silverman, D. H. S. ;

Geist, C. ;

Breen, E. C. ;

Irwin, M. R. ;

Cole, S. W. .

BRAIN BEHAVIOR AND IMMUNITY, 2013, 30 :S99-S108

[22] Interventions for cognitive deficits in adults with brain tumours [J].

Gehring, Karin ;

Sitskoorn, Margriet M. ;

Aaronson, Neil K. ;

Taphoorn, Martin J. B. .

LANCET NEUROLOGY, 2008, 7 (06) :548-560

[23] Does walking protect against decline in cognitive functioning among breast cancer patients undergoing chemotherapy? Results from a small randomised controlled trial [J].

Gokal, Kajal ;

Munir, Fehmidah ;

Ahmed, Samreen ;

Kancherla, Kiran ;

Wallis, Deborah .

PLOS ONE, 2018, 13 (11)

[24] Midlife Hypertension and 20-Year Cognitive Change The Atherosclerosis Risk in Communities Neurocognitive Study [J].

Gottesman, Rebecca F. ;

Schneider, Andrea L. C. ;

Albert, Marilyn ;

Alonso, Alvaro ;

Bandeen-Roche, Karen ;

Coker, Laura ;

Coresh, Josef ;

Knopman, David ;

Power, Melinda C. ;

Rawlings, Andreea ;

Sharrett, A. Richey ;

Wruck, Lisa M. ;

Mosley, Thomas H. .

JAMA NEUROLOGY, 2014, 71 (10) :1218-1227

[25] 'A new normal with chemobrain': Experiences of the impact of chemotherapy-related cognitive deficits in long-term breast cancer survivors [J].

Henderson, Fiona M. E. ;

Cross, Ainslea J. ;

Baraniak, Amy R. .

HEALTH PSYCHOLOGY OPEN, 2019, 6 (01)

[26] Cognitive function during neoadjuvant chemotherapy for breast cancer -: Results of a prospective, multicenter, longitudinal study [J].

Hermelink, Kerstin ;

Untch, Michael ;

Lux, Michael P. ;

Kreienberg, Rolf ;

Beck, Thomas ;

Bauerfeind, Ingo ;

Muenzel, Karin .

CANCER, 2007, 109 (09) :1905-1913

[27] The Effectiveness of Psychosocial Interventions for Cognitive Dysfunction in Cancer Patients Who Have Received Chemotherapy: A Systematic Review [J].

Hines, Sonia ;

Ramis, Mary-Anne ;

Pike, Shannon ;

Chang, Anne M. .

WORLDVIEWS ON EVIDENCE-BASED NURSING, 2014, 11 (03) :187-193

[28] Phase III, randomized, double-blind, placebo-controlled study of modafinil for fatigue in patients treated with docetaxel-based chemotherapy [J].

Hovey, Elizabeth ;

de Souza, Paul ;

Marx, Gavin ;

Parente, Phillip ;

Rapke, Tal ;

Hill, Andrew ;

Bonaventura, Antonino ;

Michele, Antony ;

Craft, Paul ;

Abdi, Ehtesham ;

Lloyd, Andrew .

SUPPORTIVE CARE IN CANCER, 2014, 22 (05) :1233-1242

[29] Associations of dietary intake and supplement use with post-therapy cognitive recovery in breast cancer survivors [J].

Huang, Zhezhou ;

Shi, Yan ;

Bao, Pingping ;

Cai, Hui ;

Hong, Zhen ;

Ding, Ding ;

Jackson, James ;

Shu, Xiao-Ou ;

Dai, Qi .

BREAST CANCER RESEARCH AND TREATMENT, 2018, 171 (01) :189-198

[30] Aging, obesity, and post-therapy cognitive recovery in breast cancer survivors [J].

Huang, Zhezhou ;

Zheng, Ying ;