Copper(II)-Catalyzed Oxidative Cross-Coupling of Anilines, Primary Alkyl Amines, and Sodium Azide Using TBHP: A Route to 2-Substituted Benzimidazoles

被引：69

作者：

Mahesh, Devulapally ^{[1
]}

Sadhu, Pradeep ^{[1
]}

Punniyamurthy, Tharmalingam ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 08期

关键词：

C-H AMINATION; N BOND FORMATION; SUBSTITUTED BENZIMIDAZOLES; ONE-POT; 1,2-DISUBSTITUTED BENZIMIDAZOLES; BIOLOGICAL EVALUATION; ARYL BENZIMIDAZOLES; CATALYZED SYNTHESIS; ALIPHATIC-AMINES; HIGHLY EFFICIENT;

D O I：

10.1021/acs.joc.6b00186

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper(II)-catalyzed oxidative cross-coupling of anilines, primary alkyl amines, and sodium azide is described in the presence of TBHP at moderate temperature. This one-pot multicomponent protocol involves a domino C-H functionalization, transimination, ortho-selective amination, and a cyclization sequence. The broad substrate scope and functional group compatibility are the significant practical features. The protocol can be extended to the coupling of benzyl alcohols with moderate yields.

引用

页码：3227 / 3234

页数：8

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