Flow-Induced Shape Reconfiguration, Phase Separation, and Rupture of Bio-Inspired Vesicles

被引：16

作者：

Chu, Xiaolei ^{[1
]}

Yu, Xiang ^{[1
]}

Greenstein, Joseph ^{[1
]}

Aydin, Fikret ^{[1
]}

Uppaladadium, Geetartha ^{[1
]}

Dutt, Meenakshi ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

来源：

ACS NANO | 2017年 / 11卷 / 07期

关键词：

dissipative particle dynamics; bio-inspired vesicles; shape recognition; Poiseuille flow; hairy lipids; rupture; RED-BLOOD-CELLS; DISSIPATIVE PARTICLE DYNAMICS; DRUG-DELIVERY; CELLULAR INTERNALIZATION; HAIRY VESICLES; DEFORMATION; SIMULATION; NANOPARTICLES; DESIGN; MOTION;

D O I：

10.1021/acsnano.7b00753

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structural integrity of red blood cells and drug delivery carriers through blood vessels is dependent upon their ability to adapt their shape during their transportation. Our goal is to examine the role of the composition of bio-inspired multicomponent and hairy vesicles on their shape during their transport through in a channel. Through the dissipative particle dynamics simulation technique, we apply Poiseuille flow in a cylindrical channel. We investigate the effect of flow conditions and concentration of key molecular components on the shape, phase separation, and structural integrity of the bio-inspired multicomponent and hairy vesicles. Our results show the Reynolds number and molecular composition of the vesicles impact their flow-induced deformation, phase separation on the outer monolayer due to the Marangoni effect, and rupture. The findings from this study could be used to enhance the design of drug delivery and tissue engineering systems.

引用

页码：6661 / 6671

页数：11

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