Flow-Induced Shape Reconfiguration, Phase Separation, and Rupture of Bio-Inspired Vesicles

被引：15
作者：
Chu, Xiaolei [1 ]
Yu, Xiang [1 ]
Greenstein, Joseph [1 ]
Aydin, Fikret [1 ]
Uppaladadium, Geetartha [1 ]
Dutt, Meenakshi [1 ]
机构：
[1] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA
来源：
ACS NANO | 2017年 / 11卷 / 07期
关键词：
dissipative particle dynamics; bio-inspired vesicles; shape recognition; Poiseuille flow; hairy lipids; rupture; RED-BLOOD-CELLS; DISSIPATIVE PARTICLE DYNAMICS; DRUG-DELIVERY; CELLULAR INTERNALIZATION; HAIRY VESICLES; DEFORMATION; SIMULATION; NANOPARTICLES; DESIGN; MOTION;
D O I：
10.1021/acsnano.7b00753
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The structural integrity of red blood cells and drug delivery carriers through blood vessels is dependent upon their ability to adapt their shape during their transportation. Our goal is to examine the role of the composition of bio-inspired multicomponent and hairy vesicles on their shape during their transport through in a channel. Through the dissipative particle dynamics simulation technique, we apply Poiseuille flow in a cylindrical channel. We investigate the effect of flow conditions and concentration of key molecular components on the shape, phase separation, and structural integrity of the bio-inspired multicomponent and hairy vesicles. Our results show the Reynolds number and molecular composition of the vesicles impact their flow-induced deformation, phase separation on the outer monolayer due to the Marangoni effect, and rupture. The findings from this study could be used to enhance the design of drug delivery and tissue engineering systems.
引用
收藏
页码：6661 / 6671
页数：11
相关论文
共 60 条
  • [1] Mesoscopic solvent simulations: Multiparticle-collision dynamics of three-dimensional flows
    Allahyarov, E
    Gompper, G
    [J]. PHYSICAL REVIEW E, 2002, 66 (03): : 1 - 036702
  • [2] Harnessing steric hindrance to control interfacial adsorption of patchy nanoparticles onto hairy vesicles
    Aydin, Fikret
    Uppaladadium, Geetartha
    Dutt, Meenakshi
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 141 : 458 - 466
  • [3] Harnessing Nanoscale Confinement to Design Sterically Stable Vesicles of Specific Shapes via Self-Assembly
    Aydin, Fikret
    Uppaladadium, Geetartha
    Dutt, Meenakshi
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2015, 119 (32) : 10207 - 10215
  • [4] The design of shape-tunable hairy vesicles
    Aydin, Fikret
    Uppaladadium, Geetartha
    Dutt, Meenakshi
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2015, 128 : 268 - 275
  • [5] Phase segregation in bio-inspired multi-component vesicles encompassing double tail phospholipid species
    Aydin, Fikret
    Ludford, Paul
    Dutt, Meenakshi
    [J]. SOFT MATTER, 2014, 10 (32) : 6096 - 6108
  • [6] Poiseuille flow to measure the viscosity of particle model fluids
    Backer, JA
    Lowe, CP
    Hoefsloot, HCJ
    Iedema, PD
    [J]. JOURNAL OF CHEMICAL PHYSICS, 2005, 122 (15)
  • [7] Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/nnano.2011.166, 10.1038/NNANO.2011.166]
  • [8] Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers
    Champion, Julie A.
    Katare, Yogesh K.
    Mitragotri, Samir
    [J]. JOURNAL OF CONTROLLED RELEASE, 2007, 121 (1-2) : 3 - 9
  • [9] Modeling Interactions between Multicomponent Vesicles and Antimicrobial Peptide-Inspired Nanoparticles
    Chu, Xiaolei
    Aydin, Fikret
    Dutt, Meenakshi
    [J]. ACS NANO, 2016, 10 (08) : 7351 - 7361
  • [10] Size and shape effects in the biodistribution of intravascularly injected particles
    Decuzzi, P.
    Godin, B.
    Tanaka, T.
    Lee, S. -Y.
    Chiappini, C.
    Liu, X.
    Ferrari, M.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2010, 141 (03) : 320 - 327
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