Expression and Function of PPARs in Cancer Stem Cells

被引：21

作者：

Zhang, Yiming ^{[1
]}

Zhang, Xu ^{[1
]}

Wang, Jing ^{[1
]}

Shen, Yun ^{[1
]}

Tang, Xiaoshan ^{[1
]}

Yu, Fang ^{[1
]}

Wang, Raorao ^{[1
]}

机构：

[1] Tongji Univ, Sch Med, Dept Stomatol, Shanghai Peoples Hosp 10, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2016年 / 11卷 / 03期

基金：

上海市自然科学基金;

关键词：

Cancer; cancer stem cells; EGF/bFGF signaling pathway; epithelial-mesenchymal transition; peroxisome-proliferator-activated receptors; Sonic hedgehog signaling pathway; ACTIVATED-RECEPTOR-ALPHA; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROBLAST-GROWTH-FACTOR; ACUTE MYELOID-LEUKEMIA; SIGNALING PATHWAY; GAMMA LIGANDS; BETA-CATENIN; IDENTIFICATION; DELTA; ADIPOGENESIS;

D O I：

10.2174/1574888X10666150728122921

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cancer stem cells (CSCs) are cancer cells with characteristics of stem cells, especially the ability to arise to all types of cell in a particular cancer tissue. With the capacity to generate multiple types of cancer cells, CSCs are proposed as primary impetus for tumor initiation and metastases and are suggested as potential therapeutic targets for anti-cancer treatment. Peroxisome-proliferator-activated receptors (PPARs) are a subset of multifunctional transcription factors which play a pivotal role in cancer development and tumorigenesis. PPARs are also reported to be involved in the modulation of the epithelial-mesenchymal transition (EMT) process in CSC initiation and in the regulation of CSC functions. However, the exact mechanisms remain unknown. Herein, we review the latest evidence on the regulatory effects and mechanisms of PPARs in CSC formation and function, and evaluate the prospects of PPARs as a target for cancer treatment.

引用

页码：226 / 234

页数：9

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