The Importance of Being Presented: Target Validation by Immunopeptidomics for Epitope-Specific Immunotherapies

被引：25

作者：

Becker, Jonas P. ^{[1
]}

Riemer, Angelika B. ^{[1
,2
]}

机构：

[1] German Canc Res Ctr, Immunotherapy & Immunoprevent, Heidelberg, Germany

[2] German Ctr Infect Res DZIF, Mol Vaccine Design, Partner Site Heidelberg, Heidelberg, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

immunopeptidomics; T cell epitope; tumor antigen; HLA class I; neoantigen; cancer immunotherapy; MHC CLASS-I; T-CELL RESPONSES; HIGH-THROUGHPUT; ANTIGENIC PEPTIDES; TAP TRANSPORT; MAJOR SOURCE; PREDICTION; IDENTIFICATION; CANCER; NEOANTIGENS;

D O I：

10.3389/fimmu.2022.883989

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Presentation of tumor-specific or tumor-associated peptides by HLA class I molecules to CD8(+) T cells is the foundation of epitope-centric cancer immunotherapies. While often in silico HLA binding predictions or in vitro immunogenicity assays are utilized to select candidates, mass spectrometry-based immunopeptidomics is currently the only method providing a direct proof of actual cell surface presentation. Despite much progress in the last decade, identification of such HLA-presented peptides remains challenging. Here we review typical workflows and current developments in the field of immunopeptidomics, highlight the challenges which remain to be solved and emphasize the importance of direct target validation for clinical immunotherapy development.

引用

页数：10

共 125 条

[41] Main Strategies for the Identification of Neoantigens [J].

Gopanenko, Alexander V. ;

Kosobokova, Ekaterina N. ;

Kosorukov, Vyacheslav S. .

CANCERS, 2020, 12 (10) :1-28

[42] Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens [J].

Gubin, Matthew M. ;

Zhang, Xiuli ;

Schuster, Heiko ;

Caron, Etienne ;

Ward, Jeffrey P. ;

Noguchi, Takuro ;

Ivanova, Yulia ;

Hundal, Jasreet ;

Arthur, Cora D. ;

Krebber, Willem-Jan ;

Mulder, Gwenn E. ;

Toebes, Mireille ;

Vesely, Matthew D. ;

Lam, Samuel S. K. ;

Korman, Alan J. ;

Allison, James P. ;

Freeman, Gordon J. ;

Sharpe, Arlene H. ;

Pearce, Erika L. ;

Schumacher, Ton N. ;

Aebersold, Ruedi ;

Rammensee, Hans-Georg ;

Melief, Cornelis J. M. ;

Mardis, Elaine R. ;

Gillanders, William E. ;

Artyomov, Maxim N. ;

Schreiber, Robert D. .

NATURE, 2014, 515 (7528) :577-+

[43] Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers [J].

Hadrup, Sine Reker ;

Bakker, Arnold H. ;

Shu, Chengyi J. ;

Andersen, Rikke S. ;

van Veluw, Jerre ;

Hombrink, Pleun ;

Castermans, Emilie ;

Straten, Per thor ;

Blank, Christian ;

Haanen, John B. ;

Heemskerk, Mirjam H. ;

Schumacher, Ton N. .

NATURE METHODS, 2009, 6 (07) :520-U79

[44] Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire [J].

Haen, Sebastian P. ;

Loeffler, Markus W. ;

Rammensee, Hans-Georg ;

Brossart, Peter .

NATURE REVIEWS CLINICAL ONCOLOGY, 2020, 17 (10) :595-610

[45] Accurate quantitation of MHC-bound peptides by application of isotopically labeled peptide MHC complexes [J].

Hassan, Chopie ;

Kester, Michel G. D. ;

Oudgenoeg, Gideon ;

de Ru, Arnaud H. ;

Janssen, George M. C. ;

Drijfhout, Jan W. ;

Spaapen, Robbert M. ;

Jimenez, Connie R. ;

Heemskerk, Mirjam H. M. ;

Falkenburg, J. H. Frederik ;

van Veelen, Peter A. .

JOURNAL OF PROTEOMICS, 2014, 109 :240-244

[46] C-terminal epitope tagging facilitates comparative ligand mapping from MHC class I positive cells [J].

Hickman, HD ;

Batson, CL ;

Prilliman, KR ;

Crawford, DL ;

Jackson, KL ;

Hildebrand, WH .

HUMAN IMMUNOLOGY, 2000, 61 (12) :1339-1346

[47] Actively personalized vaccination trial for newly diagnosed glioblastoma [J].

Hilf, Norbert ;

Kuttruff-Coqui, Sabrina ;

Frenzel, Katrin ;

Bukur, Valesca ;

Stevanovic, Stefan ;

Gouttefangeas, Cecile ;

Platten, Michael ;

Tabatabai, Ghazaleh ;

Dutoit, Valerie ;

van der Burg, Sjoerd H. ;

Straten, Per Thor ;

Martinez-Ricarte, Francisco ;

Ponsati, Berta ;

Okada, Hideho ;

Lassen, Ulrik ;

Admon, Arie ;

Ottensmeier, Christian H. ;

Ulges, Alexander ;

Kreiter, Sebastian ;

von Deimling, Andreas ;

Skardelly, Marco ;

Migliorini, Denis ;

Kroep, Judith R. ;

Idorn, Manja ;

Rodon, Jordi ;

Piro, Jordi ;

Poulsen, Hans S. ;

Shraibman, Bracha ;

McCann, Katy ;

Mendrzyk, Regina ;

Loewer, Martin ;

Stieglbauer, Monika ;

Britten, Cedrik M. ;

Capper, David ;

Welters, Marij J. P. ;

Sahuquillo, Juan ;

Kiesel, Katharina ;

Derhovanessian, Evelyna ;

Rusch, Elisa ;

Bunse, Lukas ;

Song, Colette ;

Heesch, Sandra ;

Wagner, Claudia ;

Kemmer-Bruck, Alexandra ;

Ludwig, Joerg ;

Castle, John C. ;

Schoor, Oliver ;

Tadmor, Arbel D. ;

Green, Edward ;

Fritsche, Jens .

NATURE, 2019, 565 (7738) :240-+

[48] pVACtools: A Computational Toolkit to Identify and Visualize Cancer Neoantigens [J].

Hundal, Jasreet ;

Kiwala, Susanna ;

McMichael, Joshua ;

Miller, Christopher A. ;

Xia, Huiming ;

Wollam, Alexander T. ;

Liu, Connor ;

Zhao, Sidi ;

Feng, Yang-Yang ;

Graubert, Aaron P. ;

Wollam, Amber Z. ;

Neichin, Jonas ;

Neveau, Megan ;

Walker, Jason ;

Gillanders, William ;

Mardis, Elaine R. ;

Griffith, Obi L. ;

Griffith, Malachi .

CANCER IMMUNOLOGY RESEARCH, 2020, 8 (03) :409-420

[49] Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry (Reprinted from Science, vol 255, March 6, 1992) [J].

Hunt, Donald F. ;

Henderson, Robert A. ;

Shabanowitz, Jeffrey ;

Sakaguchi, Kazuyasu ;

Michel, Hanspeter ;

Sevilir, Noelle ;

Cox, Andrea L. ;

Appella, Ettore ;

Engelhard, Victor H. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (05) :2669-2671

[50] Know thy immune self and non-self: Proteomics informs on the expanse of self and non-self, and how and where they arise [J].

Joyce, Sebastian ;

Ternette, Nicola .

PROTEOMICS, 2021, 21 (23-24)

← 1 2 3 4 5 6 7 8 9 10 →