The Importance of Being Presented: Target Validation by Immunopeptidomics for Epitope-Specific Immunotherapies

被引：25

作者：

Becker, Jonas P. ^{[1
]}

Riemer, Angelika B. ^{[1
,2
]}

机构：

[1] German Canc Res Ctr, Immunotherapy & Immunoprevent, Heidelberg, Germany

[2] German Ctr Infect Res DZIF, Mol Vaccine Design, Partner Site Heidelberg, Heidelberg, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

immunopeptidomics; T cell epitope; tumor antigen; HLA class I; neoantigen; cancer immunotherapy; MHC CLASS-I; T-CELL RESPONSES; HIGH-THROUGHPUT; ANTIGENIC PEPTIDES; TAP TRANSPORT; MAJOR SOURCE; PREDICTION; IDENTIFICATION; CANCER; NEOANTIGENS;

D O I：

10.3389/fimmu.2022.883989

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Presentation of tumor-specific or tumor-associated peptides by HLA class I molecules to CD8(+) T cells is the foundation of epitope-centric cancer immunotherapies. While often in silico HLA binding predictions or in vitro immunogenicity assays are utilized to select candidates, mass spectrometry-based immunopeptidomics is currently the only method providing a direct proof of actual cell surface presentation. Despite much progress in the last decade, identification of such HLA-presented peptides remains challenging. Here we review typical workflows and current developments in the field of immunopeptidomics, highlight the challenges which remain to be solved and emphasize the importance of direct target validation for clinical immunotherapy development.

引用

页数：10

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