Design, synthesis and identification of novel substituted isothiochromene analogs as potential antiviral and cytotoxic agents

被引：31
作者：
Abu-Hashem, Ameen A. [1 ,2 ]
Gouda, Moustafa A. [3 ,4 ]
Badria, Farid A. [5 ]
机构：
[1] Natl Res Ctr, Photochem Dept, Heterocycl Unit, Giza 12622, Egypt
[2] Jazan Univ, Dept Chem, Fac Sci, Jazan 2097, Saudi Arabia
[3] Taibah Univ, Fac Sci & Arts, Dept Chem, Ulla, Medina, Saudi Arabia
[4] Mansoura Univ, Dept Chem, Fac Sci, Mansoura 35516, Egypt
[5] Mansoura Univ, Dept Pharmacognosy, Fac Pharm, Mansoura 35516, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2018年 / 27卷 / 10期
关键词：
Isothiochromenes; Thiazolopyrimidines; Thiazines; 1,2,3-triazine; Triazolopyrimidines; Pyrrolopyrimidines; Antiviral; Antitumor activity; RAPID COLORIMETRIC ASSAY; BIOLOGICAL EVALUATION; DERIVATIVES; INHIBITORS; SURVIVAL; GROWTH;
D O I：
10.1007/s00044-018-2236-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study, we present the synthesis of novel isothiochromenes, thiazolidonone, thiazinone, arylidines, triazoles, and pyrimidinone compounds based on the starting material 3-amino- isothiochromene-4-carbonitrile 3. The chemical structures were confirmed using spectroscopic methods and elemental analyses. These compounds were screened for their in vitro antiviral and antitumor activities. Compounds 10a-c and 22a-b showed activity against herpes simplex virus-1 (HSV-1) and human immunodeficiency virus-1 (HIV-1). Compounds 15 and 21a-b exhibited activity against various types of cancer cell lines. [GRAPHICS] .
引用
收藏
页码：2297 / 2311
页数：15
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