Rational interleukin-2 therapy

被引：0
作者：
Smith, KA [1 ]
机构：
[1] Cornell Univ, Grad Sch Med Sci, Program Immunol, New York, NY 10021 USA
来源：
CANCER JOURNAL FROM SCIENTIFIC AMERICAN | 1997年 / 3卷
关键词：
immunotherapy; interleukin-2; pharmacology; structure-activity relationships; therapeutic index;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The administration of cytokines that augment the function of the immune system can be accomplished safely and without toxicity, provided a rational approach is used. Such a therapeutic method should be based upon the principles of pharmacology and the: structure-activity relationships of the cytokine-receptor interaction. Thus, the therapeutic index should be determined, and the goal should be to augment the function of the immune system in a variety of clinical situations, not necessarily focused on eradicating a particular disease process such as metastatic cancer that may or may not be influenced by the immune system.
引用
收藏
页码：S137 / S140
页数：4
相关论文
共 23 条
  • [1] EXTENDED CONTINUOUS INFUSION LOW-DOSE RECOMBINANT INTERLEUKIN-2 IN ADVANCED CANCER - PROLONGED IMMUNOMODULATION WITHOUT SIGNIFICANT TOXICITY
    CALIGIURI, MA
    MURRAY, C
    SOIFFER, RJ
    KLUMPP, TR
    SEIDEN, M
    COCHRAN, K
    CAMERON, C
    ISH, C
    BUCHANAN, L
    PERILLO, D
    SMITH, K
    RITZ, J
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (12) : 2110 - 2119
  • [2] SELECTIVE MODULATION OF HUMAN NATURAL-KILLER-CELLS INVIVO AFTER PROLONGED INFUSION OF LOW-DOSE RECOMBINANT INTERLEUKIN-2
    CALIGIURI, MA
    MURRAY, C
    ROBERTSON, MJ
    WANG, E
    COCHRAN, K
    CAMERON, C
    SCHOW, P
    ROSS, ME
    KLUMPP, TR
    SOIFFER, RJ
    SMITH, KA
    RITZ, J
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (01) : 123 - 132
  • [3] FUNCTIONAL CONSEQUENCES OF INTERLEUKIN-2 RECEPTOR EXPRESSION ON RESTING HUMAN-LYMPHOCYTES - IDENTIFICATION OF A NOVEL NATURAL-KILLER-CELL SUBSET WITH HIGH-AFFINITY RECEPTORS
    CALIGIURI, MA
    ZMUIDZINAS, A
    MANLEY, TJ
    LEVINE, H
    SMITH, KA
    RITZ, J
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (05) : 1509 - 1526
  • [4] TRANSIENT EXPRESSION OF INTERLEUKIN-2 RECEPTORS - CONSEQUENCES FOR T-CELL GROWTH
    CANTRELL, DA
    SMITH, KA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (06) : 1895 - 1911
  • [5] THE INTERLEUKIN-2 T-CELL SYSTEM - A NEW CELL-GROWTH MODEL
    CANTRELL, DA
    SMITH, KA
    [J]. SCIENCE, 1984, 224 (4655) : 1312 - 1316
  • [6] DONOHUE JH, 1983, J IMMUNOL, V130, P2203
  • [7] GILLIS S, 1978, J IMMUNOL, V120, P2027
  • [8] HALL SS, 1997, COMMOTION BLOOD LIFE, P231
  • [9] Rational interleukin 2 therapy for HIV positive individuals: Daily low doses enhance immune function without toxicity
    Jacobson, EL
    Pilaro, F
    Smith, KA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) : 10405 - 10410
  • [10] KONRAD MW, 1990, CANCER RES, V50, P2009
123