Therapeutic efficacy of bromelain in impacted third molar surgery: A randomized controlled clinical study

被引:33
作者
Ordesi, Paolo [1 ]
Pisoni, Luca [1 ]
Nannei, Pierluigi [1 ]
Macchi, Maurizia [1 ]
Borloni, Roberto [1 ]
Siervo, Sandro [2 ]
机构
[1] Ist Stomatol Italiano, Dept Maxillofacial Surg, I-20096 Milan, Italy
[2] Ist Stomatol Italiano, Sci & Educ Program, I-20096 Milan, Italy
来源
QUINTESSENCE INTERNATIONAL | 2014年 / 45卷 / 08期
关键词
bromelain; postoperative pain; third molar surgery; ORAL ENZYME COMBINATION; DOUBLE-BLIND; IN-VITRO; OSTEOARTHRITIS; KNEE;
D O I
10.3290/j.qi.a32237
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objective: Bromelain is the name given to a family of proteolytic enzymes obtained from Ananas comosus, the pineapple plant. It is considered a potent anti-inflammatory and anti-edematous substance. Surgery of impacted third molars in the outpatient setting is one of the procedures most often associated with postoperative pain and swelling. The aim of this study was to evaluate the efficacy of bromelain in reducing postoperative pain and swelling. Method and Materials: 80 patients were recruited to the study from patients attending the Maxillofacial Surgery Unit of the Istituto Stomatologico Italiano, Milan, Italy, for impacted third molar surgery. At time 0 when surgery was performed, patients started simultaneous antibiotic and analgesic therapy. On the following day, patients were divided into two groups. Patients in group 1 were prescribed bromelain. Patients in group 2 were prescribed only the analgesic if required. Three parameters were evaluated: pain, edema, and erythema. The first evaluation visit was performed 3 hours after surgery, the second 48 hours after surgery, and the final evaluation 7 days after surgery. Results: Postoperative pain, edema, and erythema were significantly lower in the study group than in the control group. Analgesic consumption, both in terms of days of treatment and number of tablets taken, was slightly lower in the study group. Only one adverse event was recorded, which occurred in a patient in the control group. Conclusion: The present study demonstrates an important anti-inflammatory and anti-edematous effect of bromelain. Statistical analysis shows that in the group treated with bromelain the inflammatory response was significantly less than in the control group.
引用
收藏
页码:679 / 684
页数:6
相关论文
共 19 条
[1]   Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee - a double-blind prospective randomized study [J].
Akhtar, N ;
Naseer, R ;
Farooqi, A ;
Aziz, W ;
Nazir, M .
CLINICAL RHEUMATOLOGY, 2004, 23 (05) :410-415
[2]  
[Anonymous], 2010, ALTERN MED REV, V15, P361
[3]   Relative efficacy of oral analgesics after third molar extraction [J].
Barden, J ;
Edwards, JE ;
McQuay, HJ ;
Wiffen, PJ ;
Moore, RA .
BRITISH DENTAL JOURNAL, 2004, 197 (07) :407-411
[4]  
Barth H, 2005, EUR J MED RES, V10, P325
[5]   Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway [J].
Bhui, Kulpreet ;
Prasad, Sahdeo ;
George, Jasmine ;
Shukla, Yogeshwer .
CANCER LETTERS, 2009, 282 (02) :167-176
[6]  
Bouloux Gary F, 2007, Oral Maxillofac Surg Clin North Am, V19, P117, DOI 10.1016/j.coms.2006.11.013
[7]  
Braun JM, 2005, IN VIVO, V19, P417
[8]   Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study [J].
Brien, S. ;
Lewith, G. ;
Walker, A. F. ;
Middleton, R. ;
Prescott, P. ;
Bundy, R. .
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2006, 99 (12) :841-850
[9]   The influence of bromelain on platelet count and platelet activity in vitro [J].
Gläser, D ;
Hilberg, T .
PLATELETS, 2006, 17 (01) :37-41
[10]   Dietary Effects on Development of the Human Mandibular Corpus [J].
Holmes, Megan A. ;
Ruff, Christopher B. .
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 2011, 145 (04) :615-628