A Reactivity-Driven Approach to the Discovery and Development of Gold-Catalyzed Organic Reactions

被引：398
作者：
Shapiro, Nathan D. [1 ]
Toste, F. Dean [1 ]
机构：
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
来源：
SYNLETT | 2010年 / 05期
关键词：
gold catalysis; enantioselective catalysis; cycloisomerizations; alkynes; allenes; FISCHER CARBENE COMPLEXES; C-H BOND; GOLD(I)-CATALYZED RING EXPANSION; ALPHA-DIAZOCARBONYL COMPOUNDS; TRANSITION-METAL CATALYSIS; WAGNER-MEERWEIN SHIFT; IN-VITRO SELECTION; CONIA-ENE REACTION; CYCLOISOMERIZATION REACTIONS; CYCLOADDITION REACTIONS;
D O I：
10.1055/s-0029-1219369
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Approaches to research in organic chemistry are as numerous as the reactions they describe. In this account, we describe our reactivity-based approach. Using our work in the area of gold catalysis as a background, we discuss how a focus on reaction mechanism and reactivity paradigms can lead to the rapid discovery of new synthetic tools.
引用
收藏
页码：675 / 691
页数：17
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