A Reactivity-Driven Approach to the Discovery and Development of Gold-Catalyzed Organic Reactions

被引：399

作者：

Shapiro, Nathan D. ^{[1
]}

Toste, F. Dean ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

SYNLETT | 2010年 / 05期

关键词：

gold catalysis; enantioselective catalysis; cycloisomerizations; alkynes; allenes; FISCHER CARBENE COMPLEXES; C-H BOND; GOLD(I)-CATALYZED RING EXPANSION; ALPHA-DIAZOCARBONYL COMPOUNDS; TRANSITION-METAL CATALYSIS; WAGNER-MEERWEIN SHIFT; IN-VITRO SELECTION; CONIA-ENE REACTION; CYCLOISOMERIZATION REACTIONS; CYCLOADDITION REACTIONS;

D O I：

10.1055/s-0029-1219369

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Approaches to research in organic chemistry are as numerous as the reactions they describe. In this account, we describe our reactivity-based approach. Using our work in the area of gold catalysis as a background, we discuss how a focus on reaction mechanism and reactivity paradigms can lead to the rapid discovery of new synthetic tools.

引用

页码：675 / 691

页数：17

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