Research on The Effect of Amyloid beta on Mitochondrial Dysfunction In vivo and In vitro

被引：17

作者：

Liu Ling-Ling ^{[1
]}

Sheng Bai-Yang ^{[1
]}

Gong Kai ^{[1
]}

Zhao Nan-Ming ^{[1
]}

Zhang Xiu-Fang ^{[1
]}

Tang Pei-Fu ^{[2
]}

Gong Yan-Dao ^{[1
]}

机构：

[1] Tsinghua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Sch Life Sci, Beijing 100084, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Beijing 100853, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2010年 / 37卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; mitochondria; amyloid beta; mitochondrial membrane potential; cytochrome c oxidase activity; mitochondrial membrane fluidity; ATP; ALZHEIMERS-DISEASE; PRECURSOR PROTEIN; GAMMA-SECRETASE; BRAIN; CELLS; PRESENILIN; NICASTRIN; MUTATIONS; COMPLEX; APH-1;

D O I：

10.3724/SP.J.1206.2009.00556

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the effect of A beta on mitochondrial dysfunction, cells stably transfected by human amyloid precursor protein 695 (APP) and cells stably co-transfected by familial Alzheimer's disease (FAD)-linked Swedish mutant of APP695 gene plus Delta E9 deleted presenilin1 gene (swe. Delta 9) were used to study the mitochondrial function. Swe. Delta 9 cells showed more reduce in mitochondrial membrane potential, altered complex IV activity, mitochondrial membrane fluidity and ATP content. However, these parameters in APP cells were lower than those in N2a cells stably transfected with empty vector. The similar results were observed in transgenic mice. APP/PS1(M146V/+) mice showed more reduced complex IV activity and ATP content than Tg2576 mice. These data indicated that the dose-dependent effect of A beta on mitochondrial dysfunction

引用

页码：154 / 160

页数：7

共 19 条

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