Synthesis of 1, 2-dihydroazete-3-methyl ester

被引：0

作者：

Hu, Xiaohan ^{[1
]}

Zhao, Bingbing ^{[1
]}

Zou, WenSheng ^{[1
]}

Yang, Xuehui ^{[1
]}

Zheng, Pengwu ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China

来源：

2018 4TH INTERNATIONAL CONFERENCE ON ENVIRONMENTAL SCIENCE AND MATERIAL APPLICATION | 2019年 / 252卷

关键词：

HCVNS5B POLYMERASE; INHIBITORS; DITERPENE; FORSKOLIN; CYCLASE; BRAIN; HEART;

D O I：

10.1088/1755-1315/252/2/022084

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The invention relate to 1, 2-dihydroazete-3-methyl ester and a series of derivatives, which can be used to treat cardiovascular diseases and hepatitis c virus (HCV). This research mainly describe a synthesis route of the key intermediate for synthetizing Forskolin and HCV NS5B inhibitors. The synthesis routes is mainly consist of three steps of acylation, replacement and hydrolysis. This synthesis route provides some valuable references and experimental basis for the synthesis of Forskolin and HCV NS5B inhibitors.

引用

页数：4

共 14 条

[1]

Braga Thais Baleeiro Teixeira, 2004, Sao Paulo Med. J., V122, P48, DOI 10.1590/S1516-31802004000200003

[2]

Herrmann S, 2001, ARTERIOSCLER THROMB, V21, P1529

[3]

HIDALGO IJ, 1989, GASTROENTEROLOGY, V96, P736

[4] Inhibitors of HCVNS5B polymerase:: Synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides [J].

Krueger, A. Chris ;

Madigan, Darold L. ;

Jiang, Wen W. ;

Kati, Warren M. ;

Liu, Dachun ;

Liu, Yaya ;

Maring, Clarence J. ;

Masse, Sherie ;

McDaniel, Keith F. ;

Middleton, Tim ;

Mo, Hongmei ;

Molla, Akhteruaman ;

Montgomery, Debra ;

Pratt, John K. ;

Rockway, Todd W. ;

Zhang, Rong ;

Kempf, Dale J. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (13) :3367-3370

[5] FORSKOLIN - A SPECIFIC STIMULATOR OF ADENYLYL CYCLASE OR A DITERPENE WITH MULTIPLE SITES OF ACTION [J].

LAURENZA, A ;

SUTKOWSKI, EM ;

SEAMON, KB .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (11) :442-447

[6] Trends in mortality from cardiovascular and cerebrovascular diseases in Europe and other areas of the world [J].

Levi, F ;

Lucchini, F ;

Negri, E ;

La Vecchia, C .

HEART, 2002, 88 (02) :119-124

[7] Boceprevir for Untreated Chronic HCV Genotype 1 Infection [J].

Poordad, Fred ;

McCone, Jonathan, Jr. ;

Bacon, Bruce R. ;

Bruno, Savino ;

Manns, Michael P. ;

Sulkowski, Mark S. ;

Jacobson, Ira M. ;

Reddy, K. Rajender ;

Goodman, Zachary D. ;

Boparai, Navdeep ;

DiNubile, Mark J. ;

Sniukiene, Vilma ;

Brass, Clifford A. ;

Albrecht, Janice K. ;

Bronowicki, Jean-Pierre ;

Colombato, L. ;

Curciarello, J. ;

Silva, M. ;

Tanno, H. ;

Terg, R. ;

Adler, M. ;

Langlet, P. ;

Lasser, L. ;

Nevens, F. ;

Anderson, F. ;

Bailey, R. ;

Bilodeau, M. ;

Cooper, C. ;

Feinman, S. V. ;

Heathcote, J. ;

Levstik, M. ;

Ramji, A. ;

Sherman, M. ;

Shafran, S. ;

Yoshida, E. ;

Achim, A. ;

Ben Ali, S. ;

Bigard, M-A. ;

Bonny, C. ;

Bourliere, M. ;

Boyer-Darrigrand, N. ;

Bronowicki, J-P. ;

Canva, V. ;

Couzigou, P. ;

De Ledinghen, V. ;

Guyader, D. ;

Hezode, C. ;

Larrey, D. ;

Latournerie, M. ;

Marcellin, P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (13) :1195-1206

[8]

Regev A, 2002, AM J GASTROENTEROL, V97, P2614, DOI 10.1111/j.1572-0241.2002.06038.x

[9] ORPHANIN-FQ - A NEUROPEPTIDE THAT ACTIVATES AN OPIOID-LIKE G-PROTEIN-COUPLED RECEPTOR [J].

REINSCHEID, RK ;

NOTHACKER, HP ;

BOURSON, A ;

ARDATI, A ;

HENNINGSEN, RA ;

BUNZOW, JR ;

GRANDY, DK ;

LANGEN, H ;

MONSMA, FJ ;

CIVELLI, O .

SCIENCE, 1995, 270 (5237) :792-794

[10] FORSKOLIN - UNIQUE DITERPENE ACTIVATOR OF ADENYLATE-CYCLASE IN MEMBRANES AND IN INTACT-CELLS [J].

SEAMON, KB ;

PADGETT, W ;

DALY, JW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06) :3363-3367

← 1 2 →