Synthesis of tert-butyl 4-bromo-4-formylpiperidine-1-carboxylate

被引：0

作者：

Hu, Xiaohan ^{[1
]}

Zhao, Bingbing ^{[1
]}

Zou, WenSheng ^{[1
]}

Yang, Xuehui ^{[1
]}

Zheng, Pengwu ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China

来源：

2018 4TH INTERNATIONAL CONFERENCE ON ENVIRONMENTAL SCIENCE AND MATERIAL APPLICATION | 2019年 / 252卷

关键词：

CELL; IBRUTINIB; KINASE; TUMORS;

D O I：

10.1088/1755-1315/252/2/022085

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The invention relates to tert-Butyl 4-bromo-4-formylpiperidine-1-carboxylate and a series of derivatives, which can be used to treat tumor viruses. This research mainly describe a synthesis route of key intermediate for synthetizing CDK9 inhibitors and Ibrutinib. The synthesis route is mainly consisit of three steps of Boc anhydride protection, oxidation and reduction. This synthesis route provides some valuable references and experimental basis for the synthesis of CDK9 inhibitors and Ibrutinib.

引用

页数：4

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