Synthesis of tert-butyl 4-bromo-4-formylpiperidine-1-carboxylate

被引：0

作者：

Hu, Xiaohan ^{[1
]}

Zhao, Bingbing ^{[1
]}

Zou, WenSheng ^{[1
]}

Yang, Xuehui ^{[1
]}

Zheng, Pengwu ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China

来源：

2018 4TH INTERNATIONAL CONFERENCE ON ENVIRONMENTAL SCIENCE AND MATERIAL APPLICATION | 2019年 / 252卷

关键词：

CELL; IBRUTINIB; KINASE; TUMORS;

D O I：

10.1088/1755-1315/252/2/022085

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The invention relates to tert-Butyl 4-bromo-4-formylpiperidine-1-carboxylate and a series of derivatives, which can be used to treat tumor viruses. This research mainly describe a synthesis route of key intermediate for synthetizing CDK9 inhibitors and Ibrutinib. The synthesis route is mainly consisit of three steps of Boc anhydride protection, oxidation and reduction. This synthesis route provides some valuable references and experimental basis for the synthesis of CDK9 inhibitors and Ibrutinib.

引用

页数：4

共 50 条

[1] Theoretical description of green solvents effect on electronic property and reactivity of Tert-butyl 4-formylpiperidine-1-carboxylate
Vimala, M.
Mary, S. Stella
Ramalakshmi, R.
Muthu, S.
COMPUTATIONAL AND THEORETICAL CHEMISTRY, 2021, 1201
[2] tert-Butyl 4-carbamoyl-3-methoxyimino-4-methylpiperidine-1-carboxylate
Wang, Juxian
Liu, Mingliang
Cao, Jue
Wang, Yucheng
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O2294 - U1911
[3] tert-Butyl 4-formyl-1H-imidazole-1-carboxylate
Kang, Jun-Tao
Li, Zhi-Gang
Xu, Jing-Wei
Wei, Yang
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2185 - U2644
[4] 3-allylation of tert-butyl 4-oxopiperidine-1-carboxylate
Moskalenko, A. I.
Boev, V. I.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 50 (11) : 1584 - 1589
[5] 3-allylation of tert-butyl 4-oxopiperidine-1-carboxylate
A. I. Moskalenko
V. I. Boev
Russian Journal of Organic Chemistry, 2014, 50 : 1584 - 1589
[6] SYNTHESIS AND FIRST APPLICATIONS OF A NEW CHIRAL AUXILIARY (TERT-BUTYL 2-(TERT-BUTYL)-5,5-DIMETHYL-4-OXOIMIDAZOLIDINE-1-CARBOXYLATE)
STUDER, A
HINTERMANN, T
SEEBACH, D
HELVETICA CHIMICA ACTA, 1995, 78 (05) : 1185 - 1206
[7] tert-butyl 3-(4-bromophenylsulfonyl)pyrrolidine-1-carboxylate
Yao, Zheng
Li, Zhi-Gang
Deng, Jian-Cheng
Xu, Jing-Wei
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O3485 - U3253
[8] Synthesis of tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate
Wang, Min
Wang, Wenhui
Tang, Qidong
Xu, Shan
PROCEEDINGS OF THE 2015 2ND INTERNATIONAL WORKSHOP ON MATERIALS ENGINEERING AND COMPUTER SCIENCES (IWMECS 2015), 2015, 33 : 247 - 249
[9] tert-Butyl 3-carbamoyl-4-methoxyimino-3-methylpiperidine-1-carboxylate
Chai, Yun
Wan, Zhi-Long
Guo, Hui-Yuan
Liu, Ming-Liang
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O282 - U1811
[10] (E)-tert-Butyl 4-(N '-hydroxycarbamimidoyl)piperazine-1-carboxylate
Sreenivasa, S.
Manojkumar, K. E.
Suchetan, P. A.
Mohan, N. R.
Palakshamurthy, B. S.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O3347 - +

← 1 2 3 4 5 →