EGFR signaling in renal fibrosis

被引：48

作者：

Zhuang, Shougang ^{[1
,2
,3
]}

Liu, Na ^{[1
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Nephrol, Shanghai 200092, Peoples R China

[2] Brown Univ, Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA

[3] Brown Univ, Alpert Med Sch, Providence, RI 02903 USA

来源：

KIDNEY INTERNATIONAL SUPPLEMENTS | 2014年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

EGER; fibrosis; kidney; renal epithelial cells; transforming growth factor-beta 1; EPIDERMAL-GROWTH-FACTOR; FACTOR RECEPTOR; KIDNEY-DISEASE; FACTOR-ALPHA; MESSENGER-RNA; PROGRESSION; ACTIVATION; INHIBITION; EXPRESSION; PROTEIN;

D O I：

10.1038/kisup.2014.13

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Signaling through the epidermal growth factor receptor (EGFR) is involved in regulation of multiple biological processes, including proliferation, metabolism, differentiation, and survival. Owing to its aberrant expression in a variety of malignant tumors, EGFR has been recognized as a target in anticancer therapy. Increasingly, evidence from animal studies indicates that EGFR signaling is also implicated in the development and progression of renal fibrosis. The therapeutic value of EGFR inhibition has not yet been evaluated in human kidney disease. In this article, we summarize recent research into the role of EGFR signaling in renal fibrogenesis, discuss the mechanism by which EGFR regulates this process, and consider the potential of EGFR as an antifibrotic target.

引用

页码：70 / 74

页数：5

共 51 条

[1]

2nd RD, 1998, BIOESSAYS, V20, P41

[2] Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis [J].

Anders, Hans-Joachim ;

Ryu, Mi .

KIDNEY INTERNATIONAL, 2011, 80 (09) :915-925

[3] Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis [J].

Bollee, Guillaume ;

Flamant, Martin ;

Schordan, Sandra ;

Fligny, Cecile ;

Rumpel, Elisabeth ;

Milon, Marine ;

Schordan, Eric ;

Sabaa, Nathalie ;

Vandermeersch, Sophie ;

Galaup, Ariane ;

Rodenas, Anita ;

Casal, Ibrahim ;

Sunnarborg, Susan W. ;

Salant, David J. ;

Kopp, Jeffrey B. ;

Threadgill, David W. ;

Quaggin, Susan E. ;

Dussaule, Jean-Claude ;

Germain, Stephane ;

Mesnard, Laurent ;

Endlich, Karlhans ;

Boucheix, Claude ;

Belenfant, Xavier ;

Callard, Patrice ;

Endlich, Nicole ;

Tharaux, Pierre-Louis .

NATURE MEDICINE, 2011, 17 (10) :1242-U272

[4]

Bruzzese F, 2011, J CELL PHYSIOL, V226, P2378, DOI 10.1002/jcp.22574

[5] Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury [J].

Chen, Jianchun ;

Chen, Jian-Kang ;

Harris, Raymond C. .

KIDNEY INTERNATIONAL, 2012, 82 (01) :45-52

[6] EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis [J].

Chen, Jianchun ;

Chen, Jian-Kang ;

Nagai, Kojiro ;

Plieth, David ;

Tan, Mingqi ;

Lee, Tang-Cheng ;

Threadgill, David W. ;

Neilson, Eric G. ;

Harris, Raymond C. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (02) :215-224

[7] Gefitinib attenuates transforming growth factor-β1-activated mitogen-activated protein kinases and mitogenesis in NRK-49F cells [J].

Chen, San-Cher ;

Guh, Jinn-Yuh ;

Lin, Tai-Du ;

Chiou, Shean-Jaw ;

Hwang, Chi-Ching ;

Ko, Yu-Min ;

Chuang, Lea-Yea .

TRANSLATIONAL RESEARCH, 2011, 158 (04) :214-224

[8] Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors [J].

Daub, H ;

Weiss, FU ;

Wallasch, C ;

Ullrich, A .

NATURE, 1996, 379 (6565) :557-560

[9] EGF-related growth factors in the pathogenesis of murine ARPKD [J].

Dell, KMR ;

Nemo, R ;

Sweeney, WE ;

Avner, ED .

KIDNEY INTERNATIONAL, 2004, 65 (06) :2018-2029

[10] Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6 [J].

Deribe, Yonathan Lissanu ;

Wild, Philipp ;

Chandrashaker, Akhila ;

Curak, Jasna ;

Schmidt, Mirko H. H. ;

Kalaidzidis, Yannis ;

Milutinovic, Natasa ;

Kratchmarova, Irina ;

Buerkle, Lukas ;

Fetchko, Michael J. ;

Schmidt, Philipp ;

Kittanakom, Saranya ;

Brown, Kevin R. ;

Jurisica, Igor ;

Blagoev, Blagoy ;

Zerial, Marino ;

Stagljar, Igor ;

Dikic, Ivan .

SCIENCE SIGNALING, 2009, 2 (102) :ra84

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