Protease-activated receptor-2-mediated contraction in the rat urinary bladder: the role of urinary bladder mucosa

被引：6

作者：

Nakahara, T ^{[1
]}

Kubota, Y ^{[1
]}

Mitani, A ^{[1
]}

Maruko, T ^{[1
]}

Sakamoto, K ^{[1
]}

Ishii, K ^{[1
]}

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol, Minato Ku, Tokyo 1088641, Japan

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2003年 / 367卷 / 02期

关键词：

prostaglandin; protease-activated receptor (PAR); urinary bladder; mucosa;

D O I：

10.1007/s00210-002-0687-y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role of protease-activated receptor-2 (PAR-2) in the regulation of the rat urinary bladder contractility was investigated. Both trypsin and PAR-2 activating peptide (SLIGRL-NH2) produced a concentration-dependent contractile response in the urinary bladder preparations. These contractions were abolished by removal of the urinary bladder mucosa and were significantly reduced by indomethacin (10 muM). These results suggest that activation of PAR-2 stimulates release of prostaglandins from mucosal layer and thereby contracts rat urinary bladder smooth muscles.

引用

收藏

页码：211 / 213

页数：3

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