Neuropeptides, food intake and body weight regulation: a hypothalamic focus

被引：221

作者：

Hillebrand, JJG ^{[1
]}

de Wied, D ^{[1
]}

Adan, RAH ^{[1
]}

机构：

[1] Univ Utrecht, Rudolf Magnus Inst Neurosci, Dept Med Pharmacol, NL-3584 CG Utrecht, Netherlands

来源：

PEPTIDES | 2002年 / 23卷 / 12期

关键词：

neuropeptides; food intake; body weight; energy homeostasis; hypothalamus;

D O I：

10.1016/S0196-9781(02)00269-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redundant) controlling system. Starvation as well as overfeeding lead to changes in expression levels of these neuropeptides, which act downstream of leptin, resulting in a physiological response. In this review the role of several anorexigenic and orexigenic (hypothalamic) neuropeptides on food intake and body weight regulation is summarized. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：2283 / 2306

页数：24

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