Magnetic iron oxide nanoparticles for biomedical applications

被引：87

作者：

Laurent, Sophie ^{[1
]}

Bridot, Jean-Luc ^{[1
]}

Elst, Luce Vander ^{[1
]}

Muller, Robert N. ^{[1
]}

机构：

[1] Univ Mons, Dept Gen Organ & Biomed Chem, NMR & Mol Imaging Lab, B-7000 Mons, Belgium

来源：

FUTURE MEDICINAL CHEMISTRY | 2010年 / 2卷 / 03期

关键词：

CORE-SHELL NANOPARTICLES; CONTRAST AGENTS; SUPERPARAMAGNETIC NANOPARTICLES; FE3O4; NANOPARTICLES; COATED MONOCRYSTALLINE; HYDROTHERMAL SYNTHESIS; RESONANCE ANGIOGRAPHY; IRON(III) OXIDE; DRUG-DELIVERY; RECTAL-CANCER;

D O I：

10.4155/FMC.09.164

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Due to their high magnetization, superparamagnetic iron oxide nanoparticles induce an important decrease in the transverse relaxation of water protons and are, therefore, very efficient negative MRI contrast agents. The knowledge and control of the chemical and physical characteristics of nanoparticles are of great importance. The choice of the synthesis method (microemulsions, sol-gel synthesis, laser pyrolysis, sonochemical synthesis or coprecipitation) determines the magnetic nanoparticle's size and shape, as well as its size distribution and surface chemistry. Nanoparticles can be used for numerous in vivo applications, such as MRI contrast enhancement and hyperthermia drug delivery. New developments focus on targeting through molecular imaging and cell tracking.

引用

页码：427 / 449

页数：23

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