High-Speed Ultrahigh-Resolution OCT of Bruch's Membrane in Membranoproliferative Glomerulonephritis Type 2

被引：11

作者：

Adhi, Mehreen ^{[1
]}

Read, Sarah P. ^{[1
]}

Liu, Jonathan J. ^{[2
]}

Fujimoto, James G. ^{[2
]}

Duker, Jay S. ^{[1
]}

机构：

[1] Tufts Med Ctr, New England Eye Ctr, Boston, MA USA

[2] MIT, Elect Res Lab, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

来源：

OPHTHALMIC SURGERY LASERS & IMAGING RETINA | 2014年 / 45卷 / 06期

关键词：

DRUSEN;

D O I：

10.3928/23258160-20141118-20

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 mu m beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type 2 and primary retinal diseases such as age-related macular degeneration.

引用

页码：614 / 617

页数：4

共 9 条

[1] Oligosaccharide composition is similar in drusen and dense deposits in membranoproliferative glomerulonephritis type II [J].