Of guards, decoys, baits and traps: pathogen perception in plants by type III effector sensors

被引：100
作者：
Khan, Madiha [1 ]
Subramaniam, Rajagopal [1 ,2 ]
Desveaux, Darrell [1 ,3 ]
机构：
[1] Univ Toronto, Dept Cell & Syst Biol, 25 Willcocks St, Toronto, ON M5S 3B2, Canada
[2] Agr & Agri Food Canada, KW Neatby Bldg,960 Carling Ave, Ottawa, ON K1A 0C6, Canada
[3] Univ Toronto, Ctr Anal Genome Funct & Evolut, 25 Willcocks St, Toronto, ON M5S 3B2, Canada
来源：
CURRENT OPINION IN MICROBIOLOGY | 2016年 / 29卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
PSEUDOMONAS-SYRINGAE EFFECTOR; DISEASE RESISTANCE PROTEIN; INNATE IMMUNE RECEPTOR; TRIGGERED IMMUNITY; ARABIDOPSIS RIN4; TRANSCRIPTION FACTORS; CYTOPLASMIC KINASES; STRUCTURAL BASIS; TAL EFFECTORS; HOST TARGET;
D O I：
10.1016/j.mib.2015.10.006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Effector-triggered immunity (ETI) is conferred by dominant plant resistance (R) genes, which encode predominantly nucleotide-binding and leucine-rich repeat domain proteins (NLRs), against cognate microbial avirulence (Avr) genes, which include bacterial type III secreted effectors (T3Es). The 'guard model' describes the mechanism of T3E perception by plants, whereby NLRs monitor host proteins ('sensors') for T3E-induced perturbations. This model has provided a molecular framework to understand T3E perception and has rationalized how plants can use a limited number of NLRs (similar to 160 in Arabidopsis) to contend with a potentially limitless number of evolving effectors. In this review we provide a characteristic overview of plant T3E sensors and discuss how these sensors convey the presence of T3Es to NLR proteins to activate ETI.
引用
收藏
页码：49 / 55
页数：7
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