Total Synthesis of (+)-Isatisine A

被引：128

作者：

Karadeolian, Avedis ^{[1
]}

Kerr, Michael A. ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

alkaloids; asymmetric synthesis; heterocycles; isatisine A; total synthesis; DONOR-ACCEPTOR CYCLOPROPANES; 3+2 CYCLOADDITION; ALDEHYDES; OXIDATION; INDOLES; ACID; TETRAHYDROFURANS;

D O I：

10.1002/anie.200906632

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Isatis indigotica has long been used as a source of therapeutic compounds in traditional Chinese medicine (the roots are the source of Ben Lan Gen herbal tea). In 2007 the leaves of J. indigotica yielded isatisine A, an unusual oxidized bisindole. A concise, enantiospecific total synthesis of isatisine A is reported using a homochiral cyclopropane diester to construct the key tetrahydrofuran ring. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA,.

引用

页码：1133 / 1135

页数：3

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