Enzyme-catalyzed asymmetric deacylation for the preparation of lasofoxifene (CP-336156), a selective estrogen receptor modulator

被引：20
作者：
Yang, XJ [1 ]
Reinhold, AR [1 ]
Rosati, RL [1 ]
Liu, KKC [1 ]
机构：
[1] Pfizer Inc, Cent Res, Groton, CT 06340 USA
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 25期
关键词：
D O I：
10.1021/ol006652+
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A potent and selective estrogen receptor modulator (SERM), Lasofoxifene (CP-336156), was prepared by an enzyme-catalyzed asymmetric deacylation with high optical purity and excellent yield even though the hydrolytic site is remote from the chiral centers.
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页码：4025 / 4027
页数：3
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