Direct halogenation of alcohols with halosilanes under catalyst- and organic solvent-free reaction conditions

被引：26

作者：

Ajvazi, Njomza ^{[1
]}

Stavber, Stojan ^{[1
,2
]}

机构：

[1] Jozef Stefan Int Postgrad Sch, Jamova 39, Ljubljana 1000, Slovenia

[2] Jozef Stefan Inst, Jamova 39, Ljubljana 1000, Slovenia

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 22期

关键词：

Halogenation; Alcohols; Halosilanes; Catalyst-free; Solvent-free; NUCLEOPHILIC-SUBSTITUTION; DIRECT CHLORINATION; ACTIVATION; CONVERSION; REAGENT; BROMINATION; CHLORIDES; BROMIDES; KETONES; BOND;

D O I：

10.1016/j.tetlet.2016.04.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemoselective method for the direct halogenation of different types of alcohols with halosilanes under catalyst- and solvent-free reaction conditions (SFRC) is reported. Various primary, secondary and tertiary benzyl alcohols and tertiary alkyl alcohols were directly transformed to the corresponding benzyl and alkyl halides, respectively, using chlorotrimethylsilane (TMSCI) and bromotrimethylsilane (TMSBr). (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2430 / 2433

页数：4

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