A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy

被引：2

作者：

Domi, Elisa ^{[1
]}

Hoxha, Malvina ^{[1
]}

Prendi, Emanuela ^{[2
]}

Zappacosta, Bruno ^{[1
]}

机构：

[1] Catholic Univ Our Lady Good Counsel, Fac Pharm, Dept Chem & Pharmacol Evaluat Drugs, Rruga Dritan Hoxha, Tirana 1000, Albania

[2] Catholic Univ Our Lady Good Counsel, Fac Med, Dept Biomed Sci, Rruga Dritan Hoxha, Tirana 1000, Albania

来源：

CELLS | 2021年 / 10卷 / 06期

关键词：

Duchenne muscular dystrophy; sirtuin1; inflammation; SKELETAL-MUSCLE; MDX MOUSE; MITOCHONDRIAL BIOGENESIS; QUERCETIN ENRICHMENT; METABOLIC DISEASE; OXIDATIVE STRESS; RESVERATROL; PGC-1-ALPHA; SIRTUINS; EXPRESSION;

D O I：

10.3390/cells10061380

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological targets. Sirtuin1 (SIRT1) seems to be a potential target for DMD. In muscle tissue, SIRT1 exerts anti-inflammatory and antioxidant effects. The aim of this study is to summarize all the findings of in vivo and in vitro literature studies about the potential role of SIRT1 in DMD. A systematic literature search was performed according to PRISMA guidelines. Twenty-three articles satisfied the eligibility criteria. It emerged that SIRT1 inhibition led to muscle fragility, while conversely its activation improved muscle function. Additionally, resveratrol, a SIRT1 activator, has brought beneficial effects to the skeletal, cardiac and respiratory muscles by exerting anti-inflammatory activity that leads to reduced myofiber wasting.

引用

页数：28

共 57 条

[21] Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α [J].