A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy

被引:2
作者
Domi, Elisa [1 ]
Hoxha, Malvina [1 ]
Prendi, Emanuela [2 ]
Zappacosta, Bruno [1 ]
机构
[1] Catholic Univ Our Lady Good Counsel, Fac Pharm, Dept Chem & Pharmacol Evaluat Drugs, Rruga Dritan Hoxha, Tirana 1000, Albania
[2] Catholic Univ Our Lady Good Counsel, Fac Med, Dept Biomed Sci, Rruga Dritan Hoxha, Tirana 1000, Albania
关键词
Duchenne muscular dystrophy; sirtuin1; inflammation; SKELETAL-MUSCLE; MDX MOUSE; MITOCHONDRIAL BIOGENESIS; QUERCETIN ENRICHMENT; METABOLIC DISEASE; OXIDATIVE STRESS; RESVERATROL; PGC-1-ALPHA; SIRTUINS; EXPRESSION;
D O I
10.3390/cells10061380
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological targets. Sirtuin1 (SIRT1) seems to be a potential target for DMD. In muscle tissue, SIRT1 exerts anti-inflammatory and antioxidant effects. The aim of this study is to summarize all the findings of in vivo and in vitro literature studies about the potential role of SIRT1 in DMD. A systematic literature search was performed according to PRISMA guidelines. Twenty-three articles satisfied the eligibility criteria. It emerged that SIRT1 inhibition led to muscle fragility, while conversely its activation improved muscle function. Additionally, resveratrol, a SIRT1 activator, has brought beneficial effects to the skeletal, cardiac and respiratory muscles by exerting anti-inflammatory activity that leads to reduced myofiber wasting.
引用
收藏
页数:28
相关论文
共 57 条
  • [1] Involvement of adiponectin in the pathogenesis of dystrophinopathy
    Abou-Samra, Michel
    Lecompte, Sophie
    Schakman, Olivier
    Noel, Laurence
    Many, Marie C.
    Gailly, Philippe
    Brichard, Sonia M.
    [J]. SKELETAL MUSCLE, 2015, 5
  • [2] Long-term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice
    Ballmann, Christopher
    Denney, Thomas
    Beyers, Ronald J.
    Quindry, Tiffany
    Romero, Matthew
    Selsby, Joshua T.
    Quindry, John C.
    [J]. EXPERIMENTAL PHYSIOLOGY, 2017, 102 (06) : 635 - 649
  • [3] Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice
    Ballmann, Christopher
    Denney, Thomas S.
    Beyers, Ronald J.
    Quindry, Tiffany
    Romero, Matthew
    Amin, Rajesh
    Selsby, Joshua T.
    Quindry, John C.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2017, 312 (01): : H128 - H140
  • [4] Histological and biochemical outcomes of cardiac pathology in mdx mice with dietary quercetin enrichment
    Ballmann, Christopher
    Hollinger, Katrin
    Selsby, Joshua T.
    Amin, Rajesh
    Quindry, John C.
    [J]. EXPERIMENTAL PHYSIOLOGY, 2015, 100 (01) : 12 - 22
  • [5] Are sirtuins viable targets for improving healthspan and lifespan?
    Baur, Joseph A.
    Ungvari, Zoltan
    Minor, Robin K.
    Le Couteur, David G.
    de Cabo, Rafael
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (06) : 443 - 461
  • [6] Therapeutic targeting of signaling pathways in muscular dystrophy
    Bhatnagar, Shephali
    Kumar, Ashok
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2010, 88 (02): : 155 - 166
  • [7] In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers
    Boots, Agnes W.
    Wilms, Lonneke C.
    Swennen, Els L. R.
    Kleinjans, Jos C. S.
    Bast, Aalt
    Haenen, Guido R. M. M.
    [J]. NUTRITION, 2008, 24 (7-8) : 703 - 710
  • [8] Resveratrol and Its Effects on the Vascular System
    Breuss, Johannes M.
    Atanasov, Atanas G.
    Uhrin, Pavel
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (07)
  • [9] Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management
    Bushby, Katharine
    Finkel, Richard
    Birnkrant, David J.
    Case, Laura E.
    Clemens, Paula R.
    Cripe, Linda
    Kaul, Ajay
    Kinnett, Kathi
    McDonald, Craig
    Pandya, Shree
    Poysky, James
    Shapiro, Frederic
    Tomezsko, Jean
    Constantin, Carolyn
    [J]. LANCET NEUROLOGY, 2010, 9 (01) : 77 - 93
  • [10] Gene expression in mdx mouse muscle in relation to age and exercise: aberrant mechanical-metabolic coupling and implications for pre-clinical studies in Duchenne muscular dystrophy
    Camerino, Giulia Maria
    Cannone, Maria
    Giustino, Arcangela
    Massari, Ada Maria
    Capogrosso, Roberta Francesca
    Cozzoli, Anna
    De Luca, Annamaria
    [J]. HUMAN MOLECULAR GENETICS, 2014, 23 (21) : 5720 - 5732