miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis

被引：93

作者：

Jiang, Zhenfeng ^{[1
]}

Yao, Lifen ^{[2
]}

Ma, Hongge ^{[2
]}

Xu, Panpan ^{[2
]}

Li, Zhiyan ^{[2
]}

Guo, Mian ^{[3
]}

Chen, Jianhang ^{[1
]}

Bao, Hongbo ^{[4
]}

Qiao, Shupei ^{[5
]}

Zhao, Yufang ^{[5
]}

Shen, Jia ^{[6
]}

Zhu, Minwei ^{[1
]}

Meyers, Carolyn ^{[7
]}

Ma, Guizhen ^{[8
]}

Xie, Chuncheng ^{[1
]}

Liu, Li ^{[1
]}

Wang, Haiyang ^{[1
]}

Zhang, Wang ^{[1
]}

Dong, Qi ^{[2
]}

Shen, Hong ^{[1
]}

Lin, Zhiguo ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Dept Neurosurg, Harbin, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 1, Dept Neurol, 23 Youzheng St, Harbin 150001, Heilongjiang Pr, Peoples R China

[3] Harbin Med Univ, Dept Neurosurg, Affiliated Hosp 2, Harbin, Peoples R China

[4] Harbin Med Univ, Dept Neurosurg, Canc Hosp, Harbin, Peoples R China

[5] Harbin Inst Technol, Sch Life Sci & Technol, Bio X Ctr, Harbin, Peoples R China

[6] Univ Calif Los Angeles, Orthoped Hosp, Res Ctr, Los Angeles, CA USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[8] Harbin Med Univ, Dept Operating Room, Affiliated Hosp 1, Harbin, Peoples R China

来源：

ONCOLOGY RESEARCH | 2017年 / 25卷 / 06期

关键词：

miR-214; Pyroptosis; Caspase; 1; Glioma; CANCER; MICRORNA-214; INFLAMMASOMES; EXPRESSION; GROWTH; DEATH; MICROENVIRONMENT; CARCINOGENESIS; INFLAMMATION; SUPPRESSION;

D O I：

10.3727/096504016X14813859905646

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether miRNAs regulate pyroptosis in glioma remains unknown. The current study found that caspase 1 expression was substantially increased in both glioma tissues and glioma cell lines, U87 and T98G, while miR-214 expression was significantly downregulated. Luciferase reporter assay recognized caspase 1 as a target gene of miR-214. These findings demonstrate that miR-214 could inhibit cell proliferation and migration through the regulation of pyroptosis intermediated by caspase 1 in glioma U87 and T98G cells and may suggest a novel therapeutic for the intervention of glioma.

引用

页码：1009 / 1019

页数：11

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