Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder

被引:0
作者
Boron, Agnieszka [1 ]
Smiarowska, Malgorzata [2 ]
Grzywacz, Anna [3 ]
Chmielowiec, Krzysztof [4 ]
Chmielowiec, Jolanta [4 ]
Masiak, Jolanta [5 ]
Pawlowski, Tomasz [6 ]
Larysz, Dariusz [7 ]
Ciechanowicz, Andrzej [1 ]
机构
[1] Pomeranian Med Univ, Dept Clin & Mol Biochem, Aleja Powstancow Wielkopolskich 72 St, PL-70111 Szczecin, Poland
[2] Pomeranian Med Univ, Dept Pharmacokinet & Therapeut Drug Monitoring, Aleja Powstancow Wielkopolskich 72 St, PL-70111 Szczecin, Poland
[3] Pomeranian Med Univ, Independent Lab Hlth Promot, Aleja Powstancow Wielkopolskich 72 St, PL-70111 Szczecin, Poland
[4] Univ Zielona Gora, Collegium Medicum, Dept Hyg & Epidemiol, Zyty 28 St, PL-65046 Zielona Gora, Poland
[5] Med Univ Lublin, Dept Psychiat & Psychiat Rehabil 2, Gluska 1 St, PL-20059 Lublin, Poland
[6] Wroclaw Med Univ, Div Psychotherapy & Psychosomat Med, Wyb L Pasteura 10 St, PL-50367 Wroclaw, Poland
[7] 109 Mil Hosp, Cutpatient Cinic Szczecin, Piotra Skargi 9-11 St, PL-70965 Szczecin, Poland
关键词
addiction; dual diagnosis; DRD2; gene; neuroticism; personality; rs6276; SUD; DOPAMINE D2 RECEPTOR; SINGLE-NUCLEOTIDE POLYMORPHISMS; ANIMAL-MODEL; UNIPOLAR MANIA; TRANSPORTER GENE; BIPOLAR MANIA; MISSING HERITABILITY; PERSONALITY-TRAITS; TAQ1A POLYMORPHISM; ALCOHOL-USE;
D O I
10.3390/ijerph19169955
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The study aims at looking into associations between the polymorphism rs6276 that occurs in the putative miRNA target site in the 3 ' UTR region of the DRD2 gene in patients with substance use disorder (SUD) comorbid with a maniacal syndrome (SUD MANIA). In our study, we did not state any essential difference in DRD2 rs6276 genotype frequencies in the studied samples of SUD MANIA, SUD, and control subjects. A significant result was found for the SUD MANIA group vs. SUD vs. controls on the Neuroticism Scale of NEO FFI test, and DRD2 rs6276 (p = 0.0320) accounted for 1.7% of the variance. The G/G homozygous variants were linked with lower results on the neuroticism scale in the SUD MANIA group because G/G alleles may serve a protective role in the expression of neuroticism in patients with SUD MANIA. So far, there have been no data in the literature on the relationship between the miRSNP rs6276 region in the DRD2 gene and neuroticism (personal traits) in patients with a diagnosis of substance use disorder comorbid with the affective, maniacal type disturbances related to SUD. This is the first report on this topic.
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