Emergence of Klebsiella pneumoniae carrying the novel extended-spectrum β-lactamase gene variants blaSHV-40, blaTEM-116 and the class 1 integron-associated blaGES-7 in Brazil

被引：14

作者：

Dropa, M. ^{[1
]}

Balsalobre, L. C. ^{[1
]}

Lincopan, N. ^{[4
]}

Mamizuka, E. M. ^{[2
]}

Cassettari, V. C. ^{[3
]}

Matte, G. R. ^{[1
]}

Matte, M. H. ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Publ Hlth, Publ Hlth Lab, Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Pharm, Sao Paulo, Brazil

[3] Univ Sao Paulo, Univ Hosp, Hosp Infect Control Comm, Sao Paulo, Brazil

[4] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2010年 / 16卷 / 06期

关键词：

blaGES; blaSHV; blaTEM; class; 1; integron; extended-spectrum beta-lactamase; Klebsiella pneumoniae; Latin America; PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; SOUTH-AMERICA; HOSPITALS; ARGENTINA; PREVALENCE; STRAIN; GES-1;

D O I：

10.1111/j.1469-0691.2009.02944.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A clinical Klebsiella pneumoniae isolate carrying the extended-spectrum beta-lactamase gene variants bla(SHV-40), bla(TEM-116) and bla(GES-7) was recovered. Cefoxitin and ceftazidime activity was most affected by the presence of these genes and an additional resistance to trimethoprim-sulphamethoxazole was observed. The bla(GES-7) gene was found to be inserted into a class 1 integron. These results show the emergence of novel bla(TEM) and bla(SHV) genes in Brazil. Moreover, the presence of class 1 integrons suggests a great potential for dissemination of bla(GES) genes into diverse nosocomial pathogens. Indeed, the bla(GES-7) gene was originally discovered in Enterobacter cloacae in Greece and, to our knowledge, has not been reported elsewhere.

引用

页码：630 / 632

页数：3